PMID: 6188770May 1, 1983Paper

Terbutaline modulation of human allergic skin reactions

The Journal of Allergy and Clinical Immunology
S TingR M Lavker

Abstract

Terbutaline, a preferential beta 2-adrenergic agonist, has been shown to inhibit allergen-induced histamine release in vitro. In contrast, orally administered therapeutic doses of terbutaline do not inhibit antigen-induced wheal and flare reactions. We studied the effects of local terbutaline on antigen-induced whealing response, histamine release, cellular inflammatory response, and ultramicroscopic mast cell changes in antigen-challenged skin sites in ragweed-sensitive subjects. Results showed that ragweed challenge significantly induced increased histamine release in all subjects. In contrast, no such histamine release was observed at sites challenged with antigen in the presence of terbutaline. Thus locally applied terbutaline in nontoxic doses modulates mediator release in certain allergic reactions.

Citations

Aug 1, 1996·British Journal of Pharmacology·M M TeixeiraP G Hellewell
Feb 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M JohnsonC J Whelan
Feb 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Grönneberg, O Zetterström
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C De Vos
Feb 1, 1989·British Journal of Clinical Pharmacology·J B WarrenC T Dollery
Sep 1, 1988·Clinical Allergy·B Zweiman
Mar 1, 1988·Clinical Allergy·J B WarrenR W Fuller

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