PMID: 8447723Jan 1, 1993Paper

Terephthalic acid in Sprague-Dawley rats as a hypolipidemic agent

Archiv der Pharmazie
I H HallJ J Chang

Abstract

Terephthalic acid at 20 mg/kg/day in lowered serum cholesterol and triglyceride levels in rats. The cholesterol content was lowered in the lipoprotein fractions. The effects of the agents on de novo lipid synthesis showed that similar enzymes were affected in rat liver and small intestinal mucosa cells as when compared to in vitro tissue culture cells from rats and humans, e.g. reduction of acyl CoA cholesterol acyl transferase and elevation of neutral cholesterol ester hydrolase activities suggest that net cholesterol esters deposition in foam cells should be reduced and plaque growth should be slowed. The suppression of LDL receptor binding and degradation by the drug suggest that less apoB lipoproteins are taken up by peripheral tissues. The elevated HDL receptor binding and internalization in the liver suggest that the drug accelerates cholesterol return to the liver. Additional studies show that cholesterol and bile acid secretion in the bile is elevated. However, the bile acids secreted are not lithogenic. Acute toxicity studies show that the agent appears to be safe in rodents. Two observations of increased serum alkaline phosphatase levels and increased liver vacuolation suggest some alteration of hepatic cell morpholog...Continue Reading

References

Oct 1, 1969·Journal of Pharmaceutical Sciences·J T DoluisioL Diamond
Jun 1, 1984·Journal of Pharmaceutical Sciences·I H HallP J Voorstad
Feb 1, 1982·The Journal of Clinical Investigation·A ChaitJ D Brunzell
Sep 1, 1955·The Journal of Clinical Investigation·R J HAVELJ H BRAGDON
Jul 5, 1958·Nature·A S McFARLANE
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Sep 1, 1964·Clinica Chimica Acta; International Journal of Clinical Chemistry·A T NESSA C PEACOCK
Jul 1, 1935·The Biochemical Journal·C P Stewart, E B Hendry
Mar 1, 1984·Pharmaceutical Research·I H HallC Gilbert

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Citations

Jul 1, 2005·Environmental Toxicology and Pharmacology·Guidong DaiXinru Wang
Dec 1, 2011·Toxicological Research·Du Yeon BangByung-Mu Lee
Nov 5, 2011·Critical Reviews in Toxicology·Gwendolyn L BallVirunya S Bhat

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