Teriflunomide treatment reduces B cells in patients with MS

Neurology. Neuroimmunology and Neuroinflammation
Ilaria GandogliaAntonio Uccelli

Abstract

To study the immunomodulatory effect of teriflunomide on innate and adaptive immune cell populations through a pilot, open-label, observational study in a cohort of patients with relapsing-remitting MS. Blood lymphocytes were isolated from 10 patients with MS before and after 3 or 12 months of treatment. Adaptive and innate immune cell subsets were analyzed by flow cytometry as follows: B cells (memory, regulatory, and mature subsets), T cells (effector and regulatory subsets), and natural killer (NK) cells (CD56(dim) and CD56(bright) subsets). Our results show that teriflunomide significantly reduces absolute counts of total CD19(+) B cells and mature and regulatory B-cell subsets. T cells were affected to a lesser extent, with a trend in reduction of absolute counts for both T effector CD4(+) cells (Th1, Th17 and Th1/17) and T regulatory CD8(+) and CD4(+) cells. Teriflunomide had no detectable effect on NK-cell numbers. In our small cohort, teriflunomide treatment affects mainly and significantly on B-cell numbers, while having a milder effect on T-cell numbers. Larger cohorts are necessary to confirm these findings and understand the effect of teriflunomide on the functionality of these cells.

References

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Citations

May 19, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Elizabeth A Mills, Yang Mao-Draayer
Nov 9, 2018·Expert Opinion on Pharmacotherapy·Ludwig Rasche, Friedemann Paul
Apr 7, 2020·Immunology·Tohid GharibiBehzad Baradaran
Jun 22, 2018·Nature Immunology·Rui LiAmit Bar-Or
Mar 9, 2019·Annals of Clinical and Translational Neurology·Silvia MedinaLuisa M Villar
Mar 14, 2019·F1000Research·Aaron GregsonDavid L Selwood
Jun 4, 2020·Hormones : International Journal of Endocrinology and Metabolism·Maria AnagnostouliGeorge Chrousos
Jul 28, 2020·International Journal of Molecular Sciences·Jan TraubMartin S Weber
Oct 23, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Tobias ZrzavyThomas Berger
Nov 19, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Alice LaroniAntonio Uccelli
Jun 26, 2021·Frontiers in Immunology·Krista D DiSanoAndrew R Pachner
Jul 27, 2021·Frontiers in Immunology·Caterina Veroni, Francesca Aloisi
Oct 14, 2021·Neurology. Neuroimmunology and Neuroinflammation·Elodie MartinBruno Stankoff

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Methods Mentioned

BETA
Flow
flow cytometry

Software Mentioned

- Pad Prism
GraphPad
Graph
FACSDiva

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