Abstract
In patients chronically treated with angiotensin converting-enzyme inhibitors (ACEI), typically selected doses of ephedrine do not always restore arterial blood pressure when anesthesia-induced hypotension occurs. We postulated that the administration of terlipressin, an agonist of the vasopressin system, with ephedrine more effectively restores pressure in this setting than the administration of ephedrine alone. This prospective, randomized, cross-over, double-blinded study compared terlipressin combined with ephedrine (n = 19) with ephedrine alone (n = 21) in treating hypotension at the induction of anesthesia in 40 ACEI-treated patients undergoing hypotension (mean arterial blood pressure [MAP] <65 mm Hg or <30% of baseline value) after standardized anesthetic protocol (target-controlled IV anesthesia with propofol). Data are mean +/- SD. Patient characteristics, MAP, and heart rate before and after the induction of anesthesia during hypotensive episodes were not significantly different between the two groups. After the first bolus, MAP was significantly greater in the Terlipressin-Ephedrine group (72 +/- 12 mm Hg versus 65 +/- 8 mm Hg, P < 0.05). The occurrence of a second hypotensive episode (5% versus 71%, P < 0.001), the...Continue Reading
References
Jun 1, 1992·Anesthesia and Analgesia·P ColsonB Roquefeuil
Jun 1, 1989·Hypertension·R V Sharma, R C Bhalla
Mar 1, 1985·Anesthesiology·C EcoffeyK Samii
Dec 1, 1993·Anesthesiology·Z J Bosnjak
May 1, 1994·Anesthesiology·H CarpD Garvey
Aug 1, 1994·Anesthesiology·P CoriatP Viars
Jan 1, 1994·Anesthesia and Analgesia·A W GoertzM Georgieff
Jan 1, 1993·Fundamental & Clinical Pharmacology·G TavernierP Montastruc
Apr 1, 1996·Anesthesiology·M LickerD R Morel
Apr 1, 1997·Anesthesiology·R F BrookerA C McKinley
Aug 1, 1997·Critical Care Medicine·D W LandryJ A Oliver
Oct 21, 1999·The Journal of Trauma·M B MalayR N Townsend
Feb 2, 2000·The Annals of Thoracic Surgery·D L MoralesM C Oz
Jun 1, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M LickerD R Morel
Jan 3, 2001·Anesthesia and Analgesia·M BertrandP Coriat
Mar 7, 2001·Hypertension·J N Cohn
May 11, 2001·Journal of Cardiovascular Pharmacology·R R WenzelT Philipp
Jun 29, 2001·Anesthesia and Analgesia·M W DünserW R Hasibeder
Citations
Aug 26, 2006·Anesthesia and Analgesia·Leanne Groban, John Butterworth
Nov 21, 2002·Critical Care Medicine·Hans G BoneHugo C Van Aken
Aug 11, 2005·Der Anaesthesist·K BuhreW Buhre
Apr 17, 2007·Der Anaesthesist·U Schirmer, W Schürmann
May 27, 2004·Natural Product Reports·Kenneth W Bentley
Aug 16, 2006·Expert Opinion on Drug Safety·Catherine UlbrichtDana Hackman
Sep 4, 2015·Obesity Surgery·Guido SalvettiFerruccio Santini
Nov 30, 2019·Experimental and Therapeutic Medicine·Hyunjee Kim
Aug 26, 2006·Anesthesiology·Tanja A Treschan, Jürgen Peters
Nov 7, 2003·Anaesthesia and Intensive Care·J SatoF Goto
Mar 15, 2006·Current Opinion in Anaesthesiology·Stefan JochbergerMartin W Dünser
Dec 25, 2004·Anesthesiology·Andrea MorelliPaolo Pietropaoli
Apr 27, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Justin CoxKeshav R Nayak
Jul 22, 2018·Journal of Anesthesia·Ondrej JorVladimir Cerny
May 27, 2003·Anesthesiology·Gilles BoccaraPierre Coriat
Jun 21, 2007·Anesthesia and Analgesia·Ai IshikawaYoshio Hatano
Oct 11, 2017·Critical Care Medicine·Beth L ErwinCharity J Morgan
Feb 25, 2009·Critical Care Medicine·Frédérique RyckwaertPascal H Colson
Feb 28, 2018·BMC Anesthesiology·Qiong LingQianqian Zhu
Feb 28, 2004·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ilan MatokGideon Paret
Apr 1, 2008·Journal of Cardiothoracic and Vascular Anesthesia·John G T Augoustides
Aug 8, 2008·Best Practice & Research. Clinical Anaesthesiology·Matthias LangeAndrea Morelli
Dec 1, 2009·Journal of Cardiothoracic and Vascular Anesthesia·Natalie F Holt, Kenneth L Haspel
Apr 20, 2010·Journal of Clinical Anesthesia·Marian WeisenbergReuven Zimlichmann
Feb 6, 2016·Veterinary Anaesthesia and Analgesia·Amanda E ColemanScott A Brown