Term delivery following successful treatment of choriocarcinoma with brain metastases, a case report and review of literature

Archives of Gynecology and Obstetrics
Nadereh BehtashFatemeh Ramezanzadeh

Abstract

Cerebral metastases from choriocarcinoma are a poor prognostic indicator of outcome in both the World Health Organization and FIGO classification systems. Although gestational trophoblastic neoplasia has become the most curable of gynecological malignancies, failure rate among "high-risk" patients is still high despite of the use of aggressive multidrug regimens. A 27-year-old woman (G(4)P(2)Ab(1)) presented with hemiplegia due to brain metastases of choriocarcinoma 1 year after spontaneous abortion. She underwent craniotomy and was treated with nine courses of multiple agent etoposide, methotrexate, actinomycin- etoposide, and cisplatinum (EMA-EP) regimen combined with whole brain irradiation. She delivered a term healthy child 2 years after termination of treatment. Multiagent EMA-EP chemotherapy and whole brain irradiation with craniotomy in selected patients preserves fertility and may improve a patient overall prognosis.

References

Nov 1, 1995·Gynecologic Oncology·A C EvansC B Hammond
Mar 1, 1993·Asia-Oceania Journal of Obstetrics and Gynaecology·H YokotaK Sutou
Jul 1, 1996·Acta Obstetricia Et Gynecologica Scandinavica·A AyhanA Erbengi
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M BowerK D Bagshawe
Feb 7, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·P L SempleL Van Wijk
Apr 17, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F GhaemmaghamiP Hanjani
Apr 12, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C-Y HuangW-F Cheng

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Citations

Aug 29, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Neeta KumarSmita Devani
Dec 18, 2009·Expert Review of Anticancer Therapy·Fengzhi Feng, Yang Xiang

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