Term delivery in a woman with severe congenital neutropenia, treated with growth colony stimulating factor

Human Reproduction
S J KaufmannB A McVerry

Abstract

The patient was diagnosed in childhood as having severe congenital neutropenia and had recurrent admissions with severe infections. In 1987, prior to getting married, she was sterilized. She continued to require i.v. antibiotics when she contracted a severe infection. On one occasion, she was treated with growth colony stimulating factor (G-CSF). Her increased neutrophil count was sustained following this treatment. In June 1993, she wished to start a family and underwent in-vitro fertilization (IVF) treatment. G-CSF was given prior to oocyte retrieval. She conceived on her first cycle and an ultrasound scan revealed a singleton pregnancy. Throughout the course of the pregnancy, her white cell count was monitored closely and remained at <1.0x10(9)/l. The pregnancy progressed uneventfully and at 37 weeks gestation she was admitted for G-CSF injections. At 38 weeks she was delivered of a boy weighing 3350 g, by elective Caesarean section. His white cell count was normal. This is the first case of G-CSF being used before conception and during pregnancy in a patient with congenital neutropenia. It shows that advances in cytokine therapy and close interdisciplinary liaison can lead to a successful outcome and help patients, who woul...Continue Reading

Citations

Apr 14, 2010·Journal of Inherited Metabolic Disease·Aditi I DagliDavid A Weinstein
Jan 3, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D DekaD Takkar
Jan 15, 2002·The Australian & New Zealand Journal of Obstetrics & Gynaecology·M R SangalliA McDonald
Oct 31, 2014·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Priya S KishnaniMichael S Watson
Jan 31, 2014·The Journal of Perinatal & Neonatal Nursing·Iris A FerrecchiaDavid A Weinstein
Sep 10, 2016·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Lorenza Lisa Serena LaniniJanine Reichenbach
Feb 12, 2017·American Journal of Reproductive Immunology : AJRI·Cielo Mae D MarquezMichael C Velarde
Sep 15, 2000·Clinics in Perinatology·R D ChristensenL M Rimsza

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.