Term or Preterm Cesarean Section Delivery Does Not Lead to Long-term Detrimental Consequences in Mice

Cerebral Cortex
Morgane ChiesaYehezkel Ben-Ari

Abstract

Epidemiological studies have provided contradictory data on the deleterious sequels of cesarean section (C-section) delivery and their links with developmental brain disorders such as Autism Spectrum Disorders. To gain better insight on these issues, we have now compared physiological, morphological, and behavioral parameters in vaginal, term, and preterm C-section delivered mice. We report that C-section delivery does not lead to long-term behavioral alterations though preterm C-section delivery modifies communicative behaviors in pups. Moreover, C-section delivery neither alters the gamma-aminobutyric acid (GABA) developmental excitatory to inhibitory shift nor the frequency or amplitude of glutamatergic and GABAergic postsynaptic currents in hippocampal pyramidal neurons. However, these neurons present an underdeveloped dendritic arbor at birth in pups born by C-section delivery, but this difference disappears 1 day later suggesting an accelerated growth after birth. Therefore, C-section delivery, with prematurity as an aggravating factor, induces transient developmental delays but neither impacts the GABA developmental sequence nor leads to long-term consequences in mice. The deleterious sequels of C-section delivery descri...Continue Reading

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Citations

Oct 31, 2018·Proceedings of the National Academy of Sciences of the United States of America·Ashlyn Swift-GallantS Marc Breedlove
Aug 29, 2019·Physiological Reviews·John F CryanTimothy G Dinan
Oct 17, 2018·Proceedings of the National Academy of Sciences of the United States of America·Alexandra Castillo-RuizNancy G Forger
Jul 30, 2019·Neural Plasticity·Morgane ChiesaYehezkel Ben-Ari
Nov 5, 2020·Journal of Neuroendocrinology·William Kenkel
Dec 15, 2020·Physiology & Behavior·Line Fisker ZachariassenCamilla Hartmann Friis Hansen
Mar 24, 2021·Cerebral Cortex·Morgane ChiesaYehezkel Ben-Ari
Aug 22, 2020·Current Biology : CB·Livia H MoraisJohn F Cryan
Mar 25, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Anna Rita ZuenaGemma Calamandrei
Jun 25, 2019·Annals of Nutrition & Metabolism·Martin G CodagnoneJohn F Cryan

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