Terminal alpha1,4-linked N-acetylglucosamine in Helicobacter pylori-associated intestinal metaplasia of the human stomach and gastric carcinoma cell lines

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
Bibiana FerreiraC A Reis

Abstract

Helicobacter pylori (Hp) infection is associated with the development of gastric lesions including gastritis, intestinal metaplasia (IM), and gastric carcinoma. In humans, Hp is found almost exclusively in the foveolar epithelium of the gastric mucosa and rarely colonizes the deeper portions where mucous cells of the glands produce mucins with terminal alpha1,4-GlcNAc O-glycans. This structure exerts antimicrobial activity against Hp. The development of IM in the stomach is characterized by Hp clearance from the metaplastic glands and by major alterations in the expression of mucins and mucin-carbohydrates. The present work evaluated whether terminal alpha1,4-GlcNAc and sialyl-Tn antigen are implicated in the process of Hp clearance from metaplastic glands by analyzing the expression of these antigens in different types of IM-complete (n=12) and incomplete (n=8)-and in gastric cell lines. Terminal alpha1,4-GlcNAc was not detected in IM except in a single foci of one case, indicating that this structure is not implicated in the clearance of Hp from IM, in contrast to what is observed in normal gastric mucosa. None of the gastric carcinoma cell lines studied showed terminal alpha1,4-GlcNAc, suggesting that they do not display a g...Continue Reading

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Citations

Oct 16, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Joana GomesCelso A Reis
Aug 13, 2013·Trends in Molecular Medicine·Salomé S PinhoCelso A Reis
Feb 3, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·José Alexandre FerreiraLúcio Lara Santos
Jan 18, 2015·Glycobiology·Marie Joncquel Chevalier CurtCatherine Robbe-Masselot
Jul 15, 2016·Biomolecules·Henrique O DuarteCelso A Reis
Apr 19, 2017·Glycobiology·Nina PerssonOla Blixt
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May 4, 2017·Molecular & Cellular Proteomics : MCP·Chunsheng JinNiclas G Karlsson
Apr 10, 2013·Molecular Oncology·José Alexandre FerreiraLúcio Lara Santos
Sep 16, 2018·Cell and Tissue Research·Melissa Shizue de A Yamashita, Eduardo O Melo
Jul 22, 2008·Journal of Clinical Pathology·A S Mall
Mar 16, 2017·Molecular & Cellular Proteomics : MCP·Chunsheng JinNiclas G Karlsson
May 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vasily MorozovFranz-Georg Hanisch
May 25, 2021·Frontiers in Molecular Biosciences·Rita MatosCelso A Reis
Aug 5, 2021·The FEBS Journal·Hans H WandallIeva Bagdonaite
Jan 15, 2013·Journal of Proteome Research·Catarina GomesHugo Osório

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Methods Mentioned

BETA
glycosylation
biopsies

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