Terminal arbors of single ON-center and OFF-center X and Y retinal ganglion cell axons within the ferret's lateral geniculate nucleus.

The Journal of Comparative Neurology
A RoeM Sur

Abstract

The lateral geniculate nucleus of the ferret contains not only eye-specific layers, but a further subdivision of layers A and A1 into inner and outer sublaminae that contain, respectively, ON-center and OFF-center cells (Stryker and Zahs, '83). To study how the arbors of single retinal ganglion cell axons correlate with these cellular divisions, we have examined the morphology of physiologically classified retinal axons in the ferret's lateral geniculate nucleus. As in cats, we could classify retinal axons as X or Y on the basis of a number of physiological criteria. X and Y axons have distinct patterns of termination in the lateral geniculate nucleus. Contralateral X axons innervate lamina A and ipsilateral axons lamina A1. X axons are further segregated in these laminae so that ON-center axons terminate in the inner sublamina, and OFF-center axons in the outer sublamina. We did not observe any branches of X axons innervating the medial interlaminar nucleus or the midbrain. Y axons have much larger terminal arbors and exhibit greater variation in their terminations. Generally, within layers A and A1, ON-center Y axons innervate the inner sublamina and OFF-center Y axons innervate the outer sublamina. However, they often innerv...Continue Reading

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Citations

Nov 16, 2002·Progress in Retinal and Eye Research·Masami Watanabe, Yutaka Fukuda
Jun 19, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·János A PergeVijay Balasubramanian
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Apr 3, 2001·Nature Reviews. Neuroscience·M Sur, C A Leamey
Jun 16, 2009·The Journal of Physiology·Vijay Balasubramanian, Peter Sterling
Apr 1, 1992·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·D J Tolhurst, P R Lewis

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