PMID: 9658285Jul 11, 1998Paper

Terminal dendritic sprouting and reactive synaptogenesis in the postnatal organ of Corti in culture

The Journal of Comparative Neurology
H M SobkowiczD F Luthy

Abstract

Synaptogenesis in the organ of Corti between the primary receptors, the inner hair cells, and the peripheral processes of their afferent spiral ganglion neurons in the mouse lasts for 5 days postnatally (Sobkowicz et al. [1986] J. Neurocytol. 15:693-714). The transplantation of the organ into culture at the fifth postnatal day induces a reactive sprouting of dendritic terminals and an extensive formation of new ribbon synapses within 24 hours. This reactive synaptogenesis differs strikingly from the primary synaptogenesis and has been seen thus far only in the inner hair cells. The synaptically engaged neuronal endings sprout a multitude of filopodia that intussuscept the inner hair cells. The filopodial tips contain a heavy electron-dense matter that appears to attract the synaptic ribbons, which form new synaptic contacts with the growing processes. The intensity of the filopodial growth and synaptogenesis subsides in about 3 days; the filopodia undergo resorption, leaving behind fibrous cytoplasmic plaques mostly stored in the supranuclear part of the hair cells. However, occasional filopodial growth and formation of new synaptic connections continued. The data demonstrate that any disruption or disturbance of the initial sy...Continue Reading

References

Mar 1, 1978·Otolaryngology·D B Webster, M Webster
Mar 15, 1979·Nature·M S Deol, S Gluecksohn-Waelsch
Jun 1, 1978·Journal of Neurocytology·N Hirokawa
Nov 10, 1978·Brain Research·R IrontonR L Holland
Jul 30, 1976·Science·J DiamondL Macintyre
Oct 1, 1975·Journal of Neurocytology·H M SobkowiczJ E Rose
Mar 1, 1976·Acta Oto-laryngologica·H Spoendlin, R Suter
Dec 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·H M Sobkowicz, S M Slapnick
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·S M Echteler
Jan 1, 1991·Journal of Cell Science. Supplement·P R Gordon-Weeks
Jan 1, 1990·Brain Research. Brain Research Reviews·J W McDonald, M V Johnston
Oct 15, 1990·The Journal of Comparative Neurology·B FritzschD Y Sanchez
Jan 1, 1988·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·M Anniko
Jan 22, 1987·The Journal of Comparative Neurology·A M Berglund, D K Ryugo
Dec 1, 1986·Journal of Neurocytology·H M SobkowiczC V Levenick
Nov 1, 1985·American Journal of Otolaryngology·H Spoendlin
Apr 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·L W Duchen
Jun 1, 1971·The Journal of Cell Biology·K M YamadaN K Wessells
Oct 1, 1973·Archives of Neurology·C CoërsJ M Gérard
May 1, 1974·The Annals of Otology, Rhinology, and Laryngology·L G Johnsson
Dec 1, 1983·Hearing Research·E M Keithley, M L Feldman
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A MatusK Fujiwara
Jul 1, 1981·Physiological Reviews·C W CotmanE W Harris
Jul 29, 1982·Brain Research·D B Webster, M Webster
Mar 8, 1994·The Journal of Comparative Neurology·J L PuelM Eybalin
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M Rocha, M Sur
Nov 1, 1993·Journal of Neurocytology·H M SobkowiczB K August

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Citations

Jul 12, 2002·Synapse·Hanna M SobkowiczBenjamin K August
Dec 18, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Hanna M SobkowiczSusan M Slapnick

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