PMID: 16639284Apr 28, 2006Paper

Terminal differentiation and mitogen-activated protein kinase signaling in human cholesteatoma epithelium

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Margriet A HuismanJan J Grote

Abstract

To investigate whether--in cholesteatoma epithelium--terminal differentiation, resulting in high involucrin expression, is associated with mitogen-activated protein kinase (MAPK) signaling. Alterations in specific signal transduction pathways may explain abnormal differentiation of the keratinocytes in cholesteatoma. Signaling pathways used by eukaryotic cells to transduce extracellular signals into cellular responses converge on activated mitogen-activated protein kinases, mainly extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38. Tissue samples were taken from 16 patients with acquired cholesteatoma. Histologic examination showed that 12 of the 16 cholesteatomas were inflamed. Immunohistochemical methods were used to determine expressions of involucrin and the activated form of p38, extracellular signal-regulated kinase, and c-Jun NH2-terminal kinase proteins. The results obtained from cholesteatoma tissue were compared with paired control samples from retroauricular skin. We demonstrated increased levels of involucrin and increased levels of the activated forms of p38 and ERK1/2 in cholesteatoma epithelium when compared with control samples. No abnormality was found in the activation and expression of ...Continue Reading

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Citations

May 10, 2013·The Journal of Laryngology and Otology·L Louw
Mar 26, 2013·The Journal of Clinical Investigation·Robert M HarmonKathleen J Green
Nov 9, 2007·The Laryngoscope·Margriet A HuismanJan J Grote
Aug 27, 2009·Acta Oto-laryngologica·Ki Hyung KimSungwon Chae

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