PMID: 2108971Apr 1, 1990Paper

Terminal differentiation of ectodermal epithelial stem cells of Hydra can occur in G2 without requiring mitosis or S phase

The Journal of Cell Biology
S Dübel, H C Schaller

Abstract

Using bromodeoxyuridine incorporation to label cells in S phase we found that ectodermal epithelial cells of Hydra can start and complete their terminal differentiation in the G2 phase of the cell cycle. Most of the cells traversed their last S phase before the signal for differentiation, namely excision of head or foot, was given. The S phase inhibitor aphidicolin accordingly did not inhibit head or foot specific differentiation. The results show that differentiation to either head- or foot-specific ectodermal epithelial cells can start and is completed within the same G2 phase. This is therefore the first description of a complete differentiation from a population of proliferating cells to terminally differentiated, cell cycle-arrested cells without the necessity of passing through an S phase or mitosis.

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Citations

Nov 18, 2000·Cellular Signalling·M CardenasL M Salgado
Sep 17, 2002·European Journal of Biochemistry·Sabine A H Hoffmeister-UllerichH Chica Schaller
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Khamilia BedelbaevaEllen Heber-Katz
Aug 1, 1992·The Journal of Cell Biology·D D SchlaepferH T Haigler
Sep 19, 2009·Seminars in Cell & Developmental Biology·Hiroshi WatanabeThomas W Holstein
Dec 31, 2015·Tissue Barriers·W BuzgariuB Galliot
Jun 30, 2006·Seminars in Cell & Developmental Biology·Brigitte GalliotSimona Chera
Apr 8, 2014·Differentiation; Research in Biological Diversity·Wanda BuzgariuBrigitte Galliot
Jul 13, 2006·Differentiation; Research in Biological Diversity·Fernando ArvizuLuis M Salgado
Apr 7, 2015·Molecular Biology and Evolution·Hendrik O PetersenThomas W Holstein
Jul 31, 2012·Developmental Cell·Torsten BossingDavid Shepherd
Sep 22, 2010·Cell Cycle·L Matthew ArthurE Heber-Katz
Apr 1, 1991·Current Opinion in Cell Biology·K Gull
Jul 1, 1991·Experimental Cell Research·Y A LazebnikV V Zenin
Jan 18, 2017·Nature Communications·Feng YueShihuan Kuang
Nov 5, 2019·Development·Matthias C VoggCharisios D Tsiairis
Jan 3, 2018·Developmental Biology·Wanda BuzgariuBrigitte Galliot
Jun 1, 1990·Differentiation; Research in Biological Diversity·H C SchallerL C Javois
Jul 8, 2021·Cold Spring Harbor Perspectives in Biology·Matthias Christian VoggBrigitte Galliot

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