Terminal proliferation in the partially deafferented dentate gyrus: time courses for the appearance and removal of degeneration and the replacement of lost terminals

The Journal of Comparative Neurology
R McWilliams, G Lynch

Abstract

The time courses for the appearance and removal of degenerating terminals and the loss and reappearance of intact terminals were investigated in the partially denervated inner molecular layer of the dentate gyrus of the adult rat. Dense degeneration was evident in the neuropil within 26 hours following contralateral hippocampectomy. These profiles increased rapidly in number until the maximal degree was reached at two to three days postlesion, after which the degenerating terminals were quickly removed from the neuropil. A more rapid rate of removal occurred during the 3-to 5-day survival period than from 6 to 50 days postlesion. The intact terminal population dropped 35% within two days of the lesion and remained at this level until six to eight days postlesion when the number began to steadily increase. The time course for this reappearance can be divided into two phases: a period of rapid terminal addition from 6 to 15 days followed by a phase of slower acquisition. This recovery continued until the normal synaptic density was regained by 50 to 65 days postlesion. These results indicate that a substantial proportion of degenerating endings are removed well in advance of the time at which terminal proliferation begins, sugges...Continue Reading

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Citations

Apr 27, 1981·Brain Research·J R McWilliams, G Lynch
Apr 1, 1989·Brain Research. Brain Research Reviews·P F Smith, I S Curthoys
Jun 1, 1987·Brain Research Bulletin·G Lynch, M Baudry
Jan 1, 1983·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·V K Vijayan
Nov 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A WreeT Beck
Oct 24, 2003·The Journal of Comparative Neurology·Thomas H McNeillCharles K Meshul
Oct 23, 1997·The Journal of Comparative Neurology·S D StyrenS T Dekosky
Jan 31, 2008·Journal of Speech, Language, and Hearing Research : JSLHR·Jeffrey A Kleim, Theresa A Jones
Feb 22, 1991·The Journal of Comparative Neurology·S D WangM Murray
Sep 1, 1993·Progress in Neurobiology·C H Horner
Jan 15, 1989·The Journal of Comparative Neurology·K B Seroogy, J H Fallon

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