PMID: 16634329Apr 26, 2006Paper

Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination

Human & Experimental Toxicology
S A TasduqR K Johri

Abstract

Terminalia chebula Gertn. (Combetraceae) is an important herbal drug in Ayurvedic pharmacopea. In the present study, a 95% ethanolic extract of T. chebula (fruit) (TC extract), which was chemically characterized on the basis of chebuloside II as a marker, was investigated for hepatoprotective activity against anti-tuberculosis (anti-TB) drug-induced toxicity. TC extract was found to prevent the hepatotoxicity caused by the administration of rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) (in combination) in a sub-chronic mode (12 weeks). The hepatoprotective effect of TC extract could be attributed to its prominent anti-oxidative and membrane stabilizing activities. The changes in biochemical observations were supported by histological profile.

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Citations

May 23, 2009·Journal of Medicinal Food·P KaiserR K Johri
Jul 8, 2008·Nutrition & Metabolism·Sude EminzadeFikret V Izzettin
May 1, 2009·Expert Opinion on Drug Discovery·Pulok K MukherjeeS Ponnusankar
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Feb 19, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Min-Kyung ChoiChang-Gue Son
Nov 22, 2013·BMC Complementary and Alternative Medicine·Ravindran JaganathanShanthi Palanivelu
Aug 9, 2016·Environmental Toxicology and Pharmacology·Ramanathan Raghu, Sivanesan Karthikeyan
Jul 28, 2016·Human & Experimental Toxicology·E ElmorsyW G Carter
Jan 16, 2017·Journal of Integrative Medicine·Udhaya Lavinya Baskaran, Evan Prince Sabina
Feb 18, 2011·Pharmaceutical Biology·Praveen SharmaDivakar Goli
Apr 27, 2013·Asian Pacific Journal of Tropical Biomedicine·Anwesa BagRabi Ranjan Chattopadhyay
Nov 23, 2018·Current Pharmacology Reports·Yifan BaoXiao-Bo Zhong
Nov 5, 2019·Journal of Ayurveda and Integrative Medicine·Neelam MangwaniVipin Kumar

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