Terminaliamide, a new ceramide and other phytoconstituents from the roots of Terminalia mantaly H. Perrier and their biological activities.

Natural Product Research
Jean Emmanuel Mbosso TeinkelaRui Werner Maçedo Krause

Abstract

Terminaliamide (1), a new ceramide was isolated from the roots of Terminalia mantaly H. Perrier (Combretaceae) along with 4 known compounds (2-5). The structures of the compounds were elucidated using 1D and 2D NMR spectroscopy analysis and mass spectrometry. Compound 1 exhibited moderated antibacterial activity towards Staphylococcus aureus with MIC value of 62.5 μg/mL. The crude MeOH extract (TMr) highly reduced Plasmodium falciparum growth with an IC50 value of 10.11 μg/mL, while hexane fraction (F1) highly reduced Trypanosoma brucei brucei growth with an IC50 value of 5.60 µg/mL. All tested samples presented little or no in vitro cytotoxicity on HeLa cell line. The present work confirms that T. mantaly is medicinally important and may be used effectively as an antimicrobial, an antiplasmodial and an antitrypanosomial with promising therapeutic index.

References

Mar 1, 1996·Journal of Natural Products·J H JungS S Kang
Jul 30, 1999·Journal of Natural Products·S S KangY H Kim
Apr 11, 2000·The Journal of Pharmacy and Pharmacology·R Verpoorte
Sep 29, 2001·Phytochemistry·L D KongR X Tan
Jan 5, 2002·Advances in Parasitology·S Tagboto, S Townson
Jan 11, 2003·Advances in Parasitology·Robert W Snow, Kevin Marsh
Feb 10, 2012·Journal of Natural Products·David J Newman, Gordon M Cragg
Nov 22, 2016·Natural Product Research·Ankita DurgeSmita S Kulkarni
Dec 13, 2016·Trends in Parasitology·Irene N NkumamaFaith H A Osier
Nov 29, 2017·Pharmaceutical Biology·Walaa A El-KashakIñaki Brouard
Apr 10, 2019·Polymers·Haoxi BenArthur Ragauskas

❮ Previous
Next ❯

Citations

Nov 3, 2020·Frontiers in Pharmacology·Gitishree DasJayanta Kumar Patra
Oct 9, 2021·Natural Product Research·Amal SallamMarwa Elsbaey

❮ Previous
Next ❯

Related Concepts

Related Feeds

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.