Terminally differentiated human intestinal B cells. J chain expression of IgA and IgG subclass-producing immunocytes in the distal ileum compared with mesenteric and peripheral lymph nodes

Clinical and Experimental Immunology
K Bjerke, P Brandtzaeg

Abstract

Two-colour immunofluorescence staining for intracellular J chain and IgA (or J chain and IgG) was performed on tissue sections of normal human ileal mucosa (eight adult kidney donors), mesenteric lymph nodes (MLN), peripheral lymph nodes, and palatine tonsils. The most prominent J chain positivity was seen for IgA (97.3%) and IgG (81.7%) immunocytes in the ileal lamina propria (LP). Moreover, the proportion of J chain-expressing extrafollicular immunocytes was significantly higher (P less than 0.05) in MLN than in peripheral lymph nodes for the IgA class (58.5% versus 25.6%); the same proportion for the IgG class was 45.9% versus 30.4%. In clinically normal palatine tonsils of adults, extrafollicular J chain expression was much lower than in peripheral lymph nodes; 14.2% for IgA cells and 5.5% for IgG cells. When related to subclass production, J chain expression was found to be higher for IgA2 than for IgA1 cells in all tissues examined (palatine tonsils excluded because of a small number of IgA2 cells), the difference being significant in MLN and ileal LP (P less than 0.05). The J chain positivity tended to be higher for all IgG subclasses in MLN than in peripheral lymph nodes; this difference was significant (P less than 0.0...Continue Reading

References

Nov 1, 1977·The Journal of Experimental Medicine·M E RouxM E Lamm
Jun 1, 1986·Immunological Reviews·S JalkanenE C Butcher
Oct 1, 1988·Scandinavian Journal of Immunology·F Mascart-LemoneL A Hanson
Apr 1, 1985·Cellular Immunology·P L Haber, J Mestecky
May 30, 1973·Nature: New Biology·P Brandtzaeg
Jul 1, 1971·The Journal of Experimental Medicine·S W Craig, J J Cebra

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Citations

Sep 26, 2013·Mucosal Immunology·M LinQ Pan-Hammarström
Apr 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·G Hacsek, E Savilahti
Dec 3, 1999·Immunological Reviews·P BrandtzaegT Yamanaka
Apr 4, 2001·Scandinavian Journal of Immunology·N DecroixJ P Bouvet
Aug 10, 2010·Current Opinion in Gastroenterology·Per Brandtzaeg
Sep 23, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caitlin D Castro, Martin F Flajnik
Jul 29, 2005·Immunological Reviews·Per Brandtzaeg, Finn-Eirik Johansen
May 25, 1999·Infection and Immunity·J P Bouvet, V A Fischetti
May 29, 2021·Immunological Reviews·Baweleta IshoJennifer L Gommerman
Mar 1, 1994·Kidney International·S J HarperJ Feehally

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