Termination of Transcription of Short Noncoding RNAs by RNA Polymerase II

Annual Review of Biochemistry
Karen M Arndt, Daniel Reines

Abstract

The RNA polymerase II transcription cycle is often divided into three major stages: initiation, elongation, and termination. Research over the last decade has blurred these divisions and emphasized the tightly regulated transitions that occur as RNA polymerase II synthesizes a transcript from start to finish. Transcription termination, the process that marks the end of transcription elongation, is regulated by proteins that interact with the polymerase, nascent transcript, and/or chromatin template. The failure to terminate transcription can cause accumulation of aberrant transcripts and interfere with transcription at downstream genes. Here, we review the mechanism, regulation, and physiological impact of a termination pathway that targets small noncoding transcripts produced by RNA polymerase II. We emphasize the Nrd1-Nab3-Sen1 pathway in yeast, in which the process has been extensively studied. The importance of understanding small RNA termination pathways is underscored by the need to control noncoding transcription in eukaryotic genomes.

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Citations

Nov 28, 2015·Wiley Interdisciplinary Reviews. RNA·Melanie J Fox, Amber L Mosley
Aug 15, 2015·RNA Biology·Jean-François Lemay, François Bachand
Oct 25, 2016·Journal of Molecular Biology·Matthias GrohNatalia Gromak
Mar 10, 2016·PloS One·Thomas W O'Rourke, Daniel Reines
Nov 7, 2017·Transcription·Kevin Roy, Guillaume F Chanfreau
Jul 14, 2016·F1000Research·Travis J Loya, Daniel Reines
Sep 19, 2019·Genes & Development·Deirdre C TatomerJeremy E Wilusz
Mar 19, 2020·PLoS Genetics·Jose F VictorinoAmber L Mosley
Apr 26, 2016·British Journal of Clinical Pharmacology·Kannan Sridharan, Nithya Jaideep Gogtay
Mar 25, 2017·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Abdel BelkorchiaEric Peyretaillade
May 17, 2019·Genetics·Mitchell A EllisonKaren M Arndt
Mar 9, 2019·Wiley Interdisciplinary Reviews. RNA·Sarah A PeckAmber L Mosley
Oct 4, 2017·Nucleic Acids Research·Elsa Franco-EchevarríaJosé Manuel Pérez-Cañadillas
Jul 1, 2019·Genetics·Mitchell A EllisonKaren M Arndt

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Methods Mentioned

BETA
NMR
histone exchange
histone acetylation
PAR-CLIP
SELEX
RNA-seq
dissection

Software Mentioned

PAR

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