Ternary WD40 Repeat-Containing Protein Complexes: Evolution, Composition and Roles in Plant Immunity

Frontiers in Plant Science
Jimi C MillerNicole K Clay

Abstract

Plants, like mammals, rely on their innate immune system to perceive and discriminate among the majority of their microbial pathogens. Unlike mammals, plants respond to this molecular dialog by unleashing a complex chemical arsenal of defense metabolites to resist or evade pathogen infection. In basal or non-host resistance, plants utilize signal transduction pathways to detect "non-self," "damaged-self," and "altered-self"- associated molecular patterns and translate these "danger" signals into largely inducible chemical defenses. The WD40 repeat (WDR)-containing proteins Gβ and TTG1 are constituents of two independent ternary protein complexes functioning at opposite ends of a plant immune signaling pathway. They are also encoded by single-copy genes that are ubiquitous in higher plants, implying the limited diversity and functional conservation of their respective complexes. In this review, we summarize what is currently known about the evolutionary history of these WDR-containing ternary complexes, their repertoire and combinatorial interactions, and their downstream effectors and pathways in plant defense.

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Citations

Jun 22, 2017·Cell Stress & Chaperones·Buddhi Prakash JainShyamal K Goswami
Dec 21, 2017·Plants·Bipei Zhang, Andrea Schrader
Oct 9, 2019·Biology of the Cell·Cuong Thach NguyenNguyen Hoai Nguyen
Jul 16, 2020·International Journal of Molecular Sciences·Hainan Tian, Shucai Wang
Sep 12, 2019·Journal of Applied Genetics·Volker Mohler, Melanie Stadlmeier
Sep 23, 2016·BioMed Research International·Xue ZhangGuotian Li
Apr 23, 2020·Frontiers in Plant Science·Yun Long, John Schiefelbein
Apr 1, 2020·Frontiers in Microbiology·Michael L ChenRamunas Stepanauskas
Mar 29, 2021·The FEBS Journal·Jeffrey R AllenLucia C Strader
Oct 17, 2021·Communications Biology·Abhisek ChakrabortyVineet K Sharma

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Methods Mentioned

BETA
GTPase
three-hybrid
Fluorescence
co-immunoprecipitation
immunoprecipitation

Software Mentioned

PhyML
TreeDyn
MUSCLE
PHYRE2

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