PMID: 3765656Aug 1, 1986Paper

Terpenoid biotransformation in mammals. IV Biotransformation of (+)-longifolene, (-)-caryophyllene, (-)-caryophyllene oxide, (-)-cyclocolorenone, (+)-nootkatone, (-)-elemol, (-)-abietic acid and (+)-dehydroabietic acid in rabbits

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
Y AsakawaT Takemoto

Abstract

The metabolism of (+)-longifolene, (-)-caryophyllene, (-)-caryophyllene oxide, (-)-cyclocolorenone, (+)-nootkatone, (-)-elemol, (-)-abietic acid and (+)-dehydroabietic acid was studied in rabbits. Each of these sesquiterpenoids was converted to primary, secondary or tertiary alcohols, among which the primary alcohol was predominant. A vinylic methyl group and an exomethylene group were easily hydroxylated and converted to a glycol via an epoxide in many cases. Eight new metabolites were determined by chemical and spectroscopic methods.

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Sep 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T B AdamsR A Ford
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Jun 1, 1990·Journal of Pharmaceutical Sciences·T MatsumotoY Asakawa
Dec 13, 2012·Magnetic Resonance in Chemistry : MRC·Shivani Mahajan, Inder Pal Singh
Oct 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Y AsakawaT Ishida
Nov 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T Ishida, T Matsumoto
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