Terpenyl-purines from the sea.

Marine Drugs
Marina Gordaliza

Abstract

Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity against a variety of species, including Mycobacterium tuberculosis, and also an important cytotoxic activity against several cancer cell lines, including multidrug-resistant ones. Of particular interest in this context are the asmarines (tetrahydro[1,4]diazepino[1,2,3-g,h]purines), which have shown potent antiproliferative activity against several types of human cancer cell lines. This review summarizes the sources of isolation, chemistry and bioactivity of marine alkylpurines and their bioactive derivatives.

References

Mar 1, 1992·Chemical & Pharmaceutical Bulletin·K IshidaJ Kobayashi
Apr 1, 1989·Canadian Journal of Physiology and Pharmacology·R Fathi-AfsharC E Cass
Nov 15, 1987·Archives of Biochemistry and Biophysics·M KobayashiY Ohizumi
Oct 19, 1993·European Journal of Pharmacology·P L TaoJ W Chern
May 19, 1998·Journal of Natural Products·X FuM Kelly-Borges
Oct 24, 1998·Journal of Natural Products·T Iwagawa van Soest RWM
Apr 11, 2000·Journal of Natural Products·T YosiefY Kashman
Jan 5, 2002·Chemical & Pharmaceutical Bulletin·D TasdemirC M Ireland
Jun 25, 2003·Drug Discovery Today·Burkhard Haefner
Jul 26, 2003·Journal of Natural Products·David J NewmanKenneth M Snader
Jan 24, 2004·Journal of Natural Products·Amira RudiYoel Kashman
Dec 1, 2004·Journal of Natural Products·Amira RudiYoel Kashman
Dec 31, 2004·The Journal of Organic Chemistry·Doron PappoYoel Kashman
Mar 8, 2005·Organic & Biomolecular Chemistry·Anne Kristin BakkestuenAnders Vik
Oct 22, 2005·Science·Ian Paterson, Edward A Anderson
Nov 3, 2005·Bioorganic & Medicinal Chemistry·Paola FossaMichele Forina
Nov 10, 2005·The Journal of Organic Chemistry·Daniel PlaMercedes Alvarez
Mar 28, 2006·Journal of Natural Products·Anders VikLars Bohlin
Sep 23, 2006·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Maria Augusta MedeirosJosé Carlos Roseiro
Oct 27, 2006·The Journal of Organic Chemistry·Rebecca M Wilson, Samuel J Danishefsky
Feb 21, 2007·Journal of Natural Products·David J Newman, Gordon M Cragg
Mar 29, 2007·Natural Product Reports·Brent R Copp, A Norrie Pearce
Apr 17, 2007·Trends in Microbiology·Kin S Lam
Apr 20, 2007·Bioorganic & Medicinal Chemistry·Anders VikLise-Lotte Gundersen
Sep 22, 2007·Current Opinion in Chemical Biology·Alan L Harvey
Oct 27, 2007·Chemistry & Biology·Ute Galm, Ben Shen
Dec 27, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M Gordaliza
Apr 22, 2008·Current Opinion in Chemical Biology·A Ganesan
May 29, 2008·Journal of Natural Products·Tim S BugniChris M Ireland
Jun 25, 2008·Journal of Natural Products·Jérôme AppenzellerCécile Debitus
Aug 12, 2008·Drug Discovery Today·Alan L Harvey
Aug 15, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alejandro M S Mayer, Kirk R Gustafson
Oct 16, 2008·Anti-cancer Agents in Medicinal Chemistry·D PlaM Alvarez
Nov 26, 2008·Natural Product Reports·Danielle Skropeta
Dec 20, 2008·Nature Reviews. Drug Discovery·Tadeusz F MolinskiJonel P Saludes
Jan 13, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anders VikLise-Lotte Gundersen
Jan 30, 2009·Natural Product Reports·John W BluntMichèle R Prinsep

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Citations

Mar 14, 2012·Marine Drugs·Marina Gordaliza
Feb 23, 2011·Marine Drugs·Marina Gordaliza
Nov 11, 2011·Marine Drugs·Sean D StoweJohn Cavanagh
Oct 29, 2013·Purinergic Signalling·Wolfgang FischerMichael Schaefer
Jun 18, 2015·Journal of Natural Products·Delfly B AbdjulMichio Namikoshi
May 2, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Si-Yuan PanKam-Ming Ko
Mar 10, 2018·Organic & Biomolecular Chemistry·Vladimir E OslovskySergey N Mikhailov
Jan 6, 2018·Marine Drugs·Pablo A GarcíaMaría-Ángeles Castro
Oct 20, 2012·Chemistry & Biodiversity·Jin-Rong ZhangGuo-Qiang Li
Jun 13, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dorothy A OkothRolf Müller
Jun 22, 2018·Current Protocols in Nucleic Acid Chemistry·Mikhail S DrenichevSergey N Mikhailov
Dec 15, 2010·Natural Product Reports·John W BluntMichèle R Prinsep
Jan 7, 2011·Journal of Natural Products·Fernanda R da SilvaAntonio Ferreira-Pereira

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