Terpioside B, a difucosyl GSL from the marine sponge Terpios sp. is a potent inhibitor of NO release

Bioorganic & Medicinal Chemistry
Valeria CostantinoAngela Ianaro

Abstract

Terpioside B (2a), a unique glycolipid containing two fucose residues in the furanose form in its pentasaccharide chain, was isolated from the marine sponge Terpios sp. Its complete stereostructure was solved by interpretation of mass spectrometric and NMR data along with CD and GG-MS analyses of its degradation products. Terpioside B is a potent inhibitor against LPS-induced NO release, and is considerably more active than simpler glycosphingolipids such as terpioside A and monoglucosylceramide.

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Citations

Aug 24, 2018·Marine Drugs·Iván Cheng-Sánchez, Francisco Sarabia
Dec 24, 2011·Natural Product Reports·John W BluntMichèle R Prinsep
Jun 23, 2020·Chemistry : a European Journal·Kazuki InabaKazunobu Toshima
May 15, 2019·Marine Drugs·Bilal AhmadSangdun Choi
Jan 31, 2018·Organic Letters·Xiangjing QinJianhua Ju

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