Terrusnolides A-D, new butenolides with anti-inflammatory activities from an endophytic Aspergillus from Tripterygium wilfordii

Fitoterapia
Changxing QiYonghui Zhang

Abstract

Terrusnolides A-D (1-4), four butenolides were isolated from an endophytic Aspergillus from Tripterygium wilfordii. The structures of 1-4 were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculation. It is interesting that 1 was a butenolide derived by a triple decarboxylation, while 2-4 were the metabolites with 4-benzyl-3-phenyl-5H-furan-2-one motif possessing an isopentene group fused to the benzene ring. In vitro anti-inflammatory effects of these isolates were evaluated in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. 1-4 exhibited excellent inhibitory effects on the production of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and nitric oxide (NO) in LPS-induced macrophages, comparable with the positive control (indomethacin). Those results indicated that, terrusnolides A-D might serve as new potential natural remedies for the treatment of inflammation.

Citations

Sep 30, 2019·Natural Products and Bioprospecting·Rufin Marie Kouipou Toghueo
Apr 16, 2020·Journal of Asian Natural Products Research·Dong-Yan LiYong-Hui Zhang
Apr 26, 2020·Planta medica·Pragya Paramita PalA Sajeli Begum
Oct 28, 2020·The Journal of Antibiotics·Weihao ChenYonghong Liu
Jan 23, 2021·International Journal of Molecular Sciences·Ruihong ZhengChangqi Zhao
Oct 29, 2019·The Journal of Organic Chemistry·Jack Everson, Milton J Kiefel

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