TERT mutation in glioma: Frequency, prognosis and risk

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Yang YuanMao Qing

Abstract

Telomerase reverse transcriptase (TERT) has received a great deal of attention in recent years for its role as a prognostic and predictive molecular marker of glioma. However, the results of studies examining its mutation frequency and predictive value are inconsistent, and several studies have investigated the association between TERT gene polymorphisms and gliomagenesis. We used a meta-analysis approach to examine these unsolved problems. A bibliography search using EMBASE and MEDLINE was performed to identify potentially relevant articles and conference abstracts that investigated TERT mutations in glioma. The references contained in the identified trials were also examined to identify any other relevant published or unpublished articles. Sixteen studies were included. Pooled estimates of the relative risks (RR), 95% confidence intervals (95% CI), hazard ratios (HR) and frequency were calculated. TERT mutations occurred frequently in glioblastoma (69%) and oligodendrogliomas (72%) but were less frequent in astrocytomas (24%) and oligoastrocytomas (38%). The HR for glioma patients with TERT mutations versus wild type TERT was 1.63 (95% CI 1.35-1.98). TERT polymorphisms were associated with an increased risk of glioma compared...Continue Reading

References

Oct 12, 2004·Cancer·Kenneth R HessMelissa L Bondy
Jul 7, 2009·Nature Genetics·Sanjay SheteRichard S Houlston
May 14, 2010·American Journal of Epidemiology·Minouk J SchoemakerAnthony J Swerdlow
Jan 5, 2011·Journal of Neuro-oncology·Kathleen M EganY Ann Chen
Mar 2, 2011·Cancer Genetics·Robert B JenkinsJohn K Wiencke
Jul 12, 2011·American Journal of Epidemiology·Daniel H LachanceMargaret R Wrensch
Aug 14, 2012·Human Genetics·Preetha RajaramanStephen J Chanock
Nov 2, 2012·International Journal of Cancer. Journal International Du Cancer·Beatrice MelinPreetha Rajaraman
Jan 26, 2013·Science·Franklin W HuangLevi A Garraway
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Patrick J KillelaHai Yan
Aug 21, 2013·Acta Neuropathologica·Naosuke NonoguchiHiroko Ohgaki
Oct 25, 2013·Acta Neuropathologica·Christian KoelscheAndreas von Deimling
Nov 13, 2013·Acta Neuropathologica·Zachary J ReitmanHai Yan
Jun 4, 2014·The Journal of Surgical Research·Peng ZhouYilin Yang

❮ Previous
Next ❯

Citations

May 13, 2018·Genes·Tiago Bordeira GasparJoão Vinagre
Oct 28, 2017·Current Oncology Reports·Kelly Braun, Manmeet S Ahluwalia
Oct 7, 2017·The Journal of Gene Medicine·Ying CuiShijie Mu
Feb 12, 2020·Genes·Anne-Marie GarrettChristopher McConville
Jul 11, 2020·Journal of Neuropathology and Experimental Neurology·Kristyn GalbraithTimothy E Richardson
Jan 19, 2019·Oncology Letters·Jiayu LiuYing Huang
Mar 9, 2017·Current Neurology and Neuroscience Reports·Michael KarsyHoward Colman
Jan 7, 2017·Journal of Molecular Endocrinology·Ana PestanaPaula Soares
Oct 28, 2018·International Journal of Molecular Sciences·Puja Sharma, Waldemar Debinski
Apr 4, 2021·Cancers·Nathalie OlympiosMaxime Fontanilles

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.