Tertiary structure of bacterial murein: the scaffold model.

Journal of Bacteriology
Boris A DmitrievStefan Ehlers

Abstract

Although the chemical structure and physical properties of peptidoglycan have been elucidated for some time, the precise three-dimensional organization of murein has remained elusive. Earlier published computer simulations of the bacterial murein architecture modeled peptidoglycan strands in either a regular (D. Pink, J. Moeller, B. Quinn, M. Jericho, and T. Beveridge, J. Bacteriol. 182: 5925-5930, 2000) or an irregular (A. Koch, J. Theor. Biol. 204: 533-541, 2000) parallel orientation with respect to the plasma membrane. However, after integrating published experimental data on glycan chain length distribution and the degree of peptide side chain cross-linking into this computer simulation, we now report that the proposed planar network of murein appears largely dysfunctional. In contrast, a scaffold model of murein architecture, which assumes that glycan strands extend perpendicularly to the plasma membrane, was found to accommodate published experimental evidence and yield a viable stress-bearing matrix. Moreover, this model is in accordance with the well-established principle of murein assembly in vivo, i.e., sequential attachment of strands to the preexisting structure. For the first time, the phenomenon of division plane ...Continue Reading

References

Jan 1, 1977·Journal of Bacteriology·B Westling-HäggströmB Winblad
Dec 25, 1977·Journal of Molecular Biology·R E BurgeD A Reaveley
Jan 1, 1977·Journal of Bacteriology·H Tzagoloff, R Novick
Sep 1, 1992·Journal of Bacteriology·M CaparrósM A de Pedro
Jul 1, 1992·Journal of Bacteriology·A L Koch, S Woeste
Jan 1, 1992·Electron Microscopy Reviews·L L Graham
Dec 1, 1991·Journal of Bacteriology·F B WientjesN Nanninga
Sep 1, 1991·Trends in Biochemical Sciences·L L GrahamN Nanninga
Jan 1, 1990·Research in Microbiology·J V Höltje, B Glauner
May 1, 1989·Journal of General Microbiology·M LeducJ Van Heijenoort
Jul 1, 1989·Journal of Bacteriology·R Prats, M A de Pedro
Sep 1, 1988·Microbiological Reviews·A L Koch
Jul 9, 1968·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J Baddiley
Dec 1, 1972·Bacteriological Reviews·K H Schleifer, O Kandler
May 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·M V Kelemen, H J Rogers
Jun 1, 1966·Journal of Bacteriology·A G MarrW C Trentini
Mar 1, 1994·Journal of Bacteriology·L L Graham, T J Beveridge
Feb 1, 1994·Trends in Microbiology·R J Doyle, R E Marquis
Aug 1, 1993·Journal of General Microbiology·D Gally, A R Archibald
Feb 1, 1996·Journal of Bacteriology·P Demchick, A L Koch
Aug 1, 1995·Molecular Microbiology·J T Park
Mar 1, 1996·Journal of Bacteriology·S YamadaH Suginaka
Sep 1, 1997·Journal of Bacteriology·S Cooper
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·N Nanninga
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·J V Höltje
May 9, 1998·Journal of Bacteriology·K J Begg, W D Donachie
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·P GiesbrechtJ Wecke
Apr 17, 1999·Medical Microbiology and Immunology·B A DmitrievE T Rietschel
Aug 26, 2000·International Journal of Medical Microbiology : IJMM·B A DmitrievP J Brennan
Sep 27, 2000·Journal of Bacteriology·D PinkT Beveridge
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·W LeeS Mobashery
Dec 4, 2001·Current Opinion in Microbiology·W Vollmer, J V Höltje

❮ Previous
Next ❯

Citations

Oct 7, 2008·Journal of the American Chemical Society·Tsung-Shing Andrew WangDaniel Kahne
May 8, 2009·Journal of the American Chemical Society·Shasad SharifJacob Schaefer
Oct 27, 2010·Nature Communications·Guillaume AndreYves F Dufrêne
Jul 14, 2005·Nature Reviews. Microbiology·Matthew T Cabeen, Christine Jacobs-Wagner
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Samy O MerouehShahriar Mobashery
Sep 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Emma J HayhurstSimon J Foster
Nov 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lu GanGrant J Jensen
May 20, 2004·Journal of Bacteriology·Ahmed TouhamiTerry J Beveridge
Sep 3, 2004·Journal of Bacteriology·Waldemar Vollmer, Joachim-Volker Höltje
Oct 19, 2004·Journal of Bacteriology·Boris A DmitrievS Ehlers
Apr 20, 2004·Journal of Bacteriology·Miguel A de PedroHeinz Schwarz
Dec 1, 2011·Microbiology and Molecular Biology Reviews : MMBR·Sean X Sun, Hongyuan Jiang
Mar 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Erik C Hett, Eric J Rubin
Dec 13, 2005·Microbiology and Molecular Biology Reviews : MMBR·Dirk-Jan Scheffers, Mariana G Pinho
Mar 22, 2008·Annual Review of Biochemistry·Dylan M Morris, Grant J Jensen
Mar 4, 2014·PLoS Computational Biology·James C GumbartBenoît Roux
Aug 12, 2014·Trends in Pharmacological Sciences·Agnieszka GórskaMichał Piotr Marszałł
Jun 11, 2014·Biochimica Et Biophysica Acta·Sung Joon KimManmilan Singh
Jun 23, 2009·Journal of Molecular Biology·Sung Joon KimJacob Schaefer
Mar 13, 2009·The EMBO Journal·Matthew T CabeenChristine Jacobs-Wagner
Mar 28, 2013·Molecular Microbiology·Elitza I TochevaGrant J Jensen
Jan 11, 2014·Molecular Microbiology·Robert D TurnerSimon J Foster
Mar 29, 2014·Molecular Microbiology·Eiji TamaiShigehiro Kamitori
Mar 7, 2006·Trends in Microbiology·Kevin D Young
Oct 21, 2005·Trends in Microbiology·Boris DmitrievStefan Ehlers
Jun 19, 2012·Molecular Membrane Biology·Phillip E KlebbaSalete M Newton
Jan 16, 2008·FEMS Microbiology Reviews·Waldemar VollmerMiguel A de Pedro
May 13, 2008·Journal of Structural Biology·Jacques IzardMichael Marko
Jan 12, 2010·Trends in Microbiology·Waldemar Vollmer, Stephen J Seligman
Mar 27, 2007·Biochimica Et Biophysica Acta·Manuel Nuno Melo, Miguel A R B Castanho
Jun 1, 2016·Nature Reviews. Microbiology·Andrea Du Toit
Mar 13, 2016·Applied and Environmental Microbiology·Alex G LiYun Xing
Jan 21, 2016·Journal of Bacteriology·Phillip E Klebba
Mar 30, 2018·Annual Review of Biochemistry·Atanas D RadkovMichael S VanNieuwenhze

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.