Tesaglitazar: a promising approach in type 2 diabetes

Drugs of Today
Sandra L Cox

Abstract

While glycemic control remains the cornerstone of clinical management for patients with type 2 diabetes, the importance of a more comprehensive approach that addresses the multiple metabolic abnormalities seen in this population is now widely recognized. Abnormal lipid metabolism resulting in dyslipidemia contributes greatly to the markedly increased risks of cardiovascular disease observed in diabetic patients and in prediabetic patients with signs of insulin resistance. The peroxisome proliferator-activated receptors (PPARs) play a key role in the regulation of energy homeostasis and the coordination of inflammatory responses. As such, they are interesting targets for addressing both the glucose and lipid abnormalities associated with insulin resistance. The thiazolidinediones (TZDs), which activate PPARgamma, appear to improve glycemic control primarily by increasing peripheral insulin sensitivity and reducing hepatic glucose production, thereby helping to preserve beta-cell function. They have also demonstrated modest beneficial effects on some lipid parameters. The fibrate drugs, which activate PPARalpha, produce robust improvements in dyslipidemia, decrease atherosclerotic lesions and may have an effect on cardiovascular ...Continue Reading

Citations

Oct 4, 2011·The Open Medicinal Chemistry Journal·Ernest AdeghateHuba Kalasz
Mar 28, 2008·Archives of Pharmacal Research·YoonJung KimRaok Jeon
Sep 25, 2012·Heart Failure Clinics·Jeong-a KimMichael J Quon
Aug 19, 2014·Bioorganic & Medicinal Chemistry Letters·Gabriel Navarrete-VázquezJulio César Almanza-Pérez
Apr 13, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pitchai BalakumarManjeet Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.