Test 1 analyser for determination of ESR. 2. Experimental evaluation and comparison with RBC aggregometry

Scandinavian Journal of Clinical and Laboratory Investigation
Max R HardemanAnna A Bouman

Abstract

Test 1 is a recently introduced technique claiming to determine Erythrocyte Sedimentation Rate (ESR) in 20 s. In contrast to the original Westergren procedure this new technique uses undiluted blood and operates at 37 degrees C. It is hypothesized that Test 1 is in fact an erythrocyte aggregometer and does not measure any sedimentation. Test 1 results were compared to those obtained with StaRRsed, an automated ESR analyser based on the Westergren technique, and the results of both were correlated to various indices of red blood cell (RBC) aggregation, obtained with an aggrego--meter (LORCA). Measurements were made on blood from 75 patients with various rheumatic disorders. Furthermore, blood that was experimentally manipulated in order to affect RBC aggregation, i.e. by changing the hematocrit, by diminishing plasma protein concentration, by inducing hyperaggregation or by RBC rigidification, was tested on all three instruments. Generally in patient blood, Test 1 results demonstrated a higher correlation with the various aggregation parameters than StaRRsed. Highest correlation (R = -0.8)) with both Test 1 and StaRRsed outcome were seen with I(20), a RBC aggregation parameter directly related to the backscatter intensity. All e...Continue Reading

References

Jan 1, 1988·Biorheology·A Gaspar-Rosas, G B Thurston
Sep 5, 1998·American Journal of Clinical Pathology·M PlebaniE Stockreiter
Mar 6, 2003·IEEE Transactions on Bio-medical Engineering·Johannes G G DobbeCornelis A Grimbergen
Nov 26, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·Max R HardemanAnna A Bouman

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Citations

Dec 30, 2014·Clinical Hemorheology and Microcirculation·Baris OzturkNeslihan H Dikmenoglu-Falkmarken
Oct 23, 2014·Clinical Hemorheology and Microcirculation·Nathalie LemonnePhilippe Connes
Sep 22, 2010·American Journal of Clinical Pathology·Joyce CurversMartien Herruer
Mar 1, 2011·International Journal of Laboratory Hematology·J M JouUNKNOWN International Council for Standardization in Haematology
Feb 16, 2021·Scandinavian Journal of Clinical and Laboratory Investigation·Massimo PieriSergio Bernardini
May 5, 2021·The American Journal of the Medical Sciences·Benoît Thomas, Sabine Revuz

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