Test characteristics of the SD FK80 Plasmodium falciparum/Plasmodium vivax malaria rapid diagnostic test in a non-endemic setting.

Malaria Journal
Philippe GilletJan Jacobs

Abstract

The SD FK80 P.f/P.v Malaria Antigen Rapid Test (Standard Diagnostics, Korea) (FK80) is a three-band malaria rapid diagnostic test detecting Plasmodium falciparum histidine-rich protein-2 (HRP-2) and Plasmodium vivax-specific lactate dehydrogenase (Pv-pLDH). The present study assessed its performance in a non-endemic setting. Stored blood samples (n = 416) from international travellers suspected of malaria were used, with microscopy corrected by PCR as the reference method. Samples infected by Plasmodium falciparum (n = 178), Plasmodium vivax (n = 99), Plasmodium ovale (n = 75) and Plasmodium malariae (n = 24) were included, as well as 40 malaria negative samples. Overall sensitivities for the diagnosis of P. falciparum and P. vivax were 91.6% (95% confidence interval (CI): 86.2% - 95.0%) and 75.8% (65.9% - 83.6%). For P. falciparum, sensitivity at parasite densities >or= 100/microl was 94.6% (88.8% - 97.6%); for P. vivax, sensitivity at parasite densities >or= 500/microl was 86.8% (75.4% - 93.4%). Four P. falciparum samples showed a Pv-pLDH line, three of them had parasite densities exceeding 50.000/microl. Two P. vivax samples, one P. ovale and one P. malariae sample showed a HRP-2 line. For the HRP-2 and Pv-pLDH lines, respec...Continue Reading

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Citations

May 3, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael L Wilson
Sep 15, 2012·Malaria Journal·Barbara BarbéJan Jacobs
Jul 24, 2010·Malaria Journal·Philippe GilletJan Jacobs
Jan 10, 2013·Microbial Biotechnology·Raweewan ThiramanasDuangporn Polpanich
Sep 13, 2014·Parasitology·Peter L Chiodini
Feb 5, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J MalthaJ Jacobs
Jan 15, 2014·BMC Public Health·Dawit G AyeleHenry G Mwambi
Dec 5, 2014·Tropical Medicine and Health·Ryutaro TanizakiNorio Ohmagari
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Jul 8, 2011·The Cochrane Database of Systematic Reviews·Katharine AbbaPaul Garner
Jun 14, 2012·Malaria Journal·Dawit G AyeleHenry G Mwambi

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Methods Mentioned

BETA
PCR
light microscopy

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