Test of dynamic closed-loop baroreflex and autoregulatory control of total peripheral resistance in intact and conscious sheep

American Journal of Physiology. Heart and Circulatory Physiology
Nikolai AljuriR J Cohen

Abstract

This is the first study able to examine and delineate the actual actions of the physiological mechanisms responsible for the dynamic couplings between cardiac output (CO), arterial pressure (Pa), right atrial pressure (PRA), and total peripheral resistance (TPR) in an individual subject without altering the underlying regulatory mechanisms. Eight conscious male sheep were used, where both types of baroreceptors were independently exposed to simultaneous beat-to-beat pressure perturbations under intact closed-loop conditions while CO, Pa, PRA, and TPR were measured. We applied the cardiovascular system identification method proposed in a companion paper (4) to quantitatively characterize the dynamic closed-loop transfer relations CO-->Pa, PRA-->Pa, Pa-->TPR, and PRA-->TPR from the measured signals. To validate the dynamic properties of the estimated transfer relations, the essential parts of the linear dynamics of the model were independently and comprehensively evaluated via error model cross-validation, and the overall model's steady-state behavior was compared with a separate random effects regression approach. In addition to numerous physiological findings, we found that the cardiovascular system identification results were ...Continue Reading

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Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Nikolai Aljuri, Richard J Cohen

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Citations

Jul 28, 2009·Nonlinear Biomedical Physics·Federico AlettiGiuseppe Baselli
Nov 19, 2011·Psychophysiology·Evgeny G VaschilloMarsha E Bates
Jul 3, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Nikolai Aljuri, Richard J Cohen
Mar 31, 2005·Physiological Measurement·Xinshu XiaoRamakrishna Mukkamala
Nov 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Xiaoxiao ChenRamakrishna Mukkamala

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