Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey

Arteriosclerosis : an Official Journal of the American Heart Association, Inc
I D FrantzE R Brewer


The Minnesota Coronary Survey was a 4.5-year, open enrollment, single end-time double-blind, randomized clinical trial that was conducted in six Minnesota state mental hospitals and one nursing home. It involved 4393 institutionalized men and 4664 institutionalized women. The trial compared the effects of a 39% fat control diet (18% saturated fat, 5% polyunsaturated fat, 16% monounsaturated fat, 446 mg dietary cholesterol per day) with a 38% fat treatment diet (9% saturated fat, 15% polyunsaturated fat, 14% monounsaturated fat, 166 mg dietary cholesterol per day) on serum cholesterol levels and the incidence of myocardial infarctions, sudden deaths, and all-cause mortality. The mean duration of time on the diets was 384 days, with 1568 subjects consuming the diet for over 2 years. The mean serum cholesterol level in the pre-admission period was 207 mg/dl, falling to 175 mg/dl in the treatment group and 203 mg/dl in the control group. For the entire study population, no differences between the treatment and control groups were observed for cardiovascular events, cardiovascular deaths, or total mortality. A favorable trend for all these end-points occurred in some younger age groups.


Mar 5, 2009·European Journal of Nutrition·J Bruce GermanFrédéric Destaillats
Dec 21, 2000·Current Atherosclerosis Reports·M E Brousseau, Ernst J Schaefer
Oct 4, 2002·Current Atherosclerosis Reports·S Renaud, D Lanzmann-Petithory
Nov 1, 2005·Current Atherosclerosis Reports·Dariush Mozaffarian
Jul 25, 2009·Current Treatment Options in Cardiovascular Medicine·Christopher E RamsdenLaurence S Sperling
Aug 1, 1994·Atherosclerosis·J C LaRosa
Jan 1, 1995·Molecular Aspects of Medicine·M J Halpern
Aug 1, 1994·Social Science & Medicine·D M Atrens
Mar 21, 1998·Cardiology Clinics·S J Lewis
Jul 10, 2002·Journal of the American College of Cardiology·Gavin J BlakeKaren M Kuntz
Jan 16, 1998·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Renaud
Jun 18, 2011·The British Journal of Nutrition·Christopher E RamsdenJohn M Davis
Jun 29, 1995·The New England Journal of Medicine·J W Rich-EdwardsJ E Buring
Oct 31, 2001·Public Health Nutrition·S Renaud, D Lanzmann-Petithory
Jul 25, 2012·Population Health Management·Alyssa B SchultzDee W Edington
Apr 1, 1997·Journal of Clinical Pharmacy and Therapeutics·W Y Zhang, A L Po
Apr 1, 1997·Journal of Clinical Pharmacy and Therapeutics·U Martin, C Eagles
Mar 1, 1995·Clinical and Experimental Pharmacology & Physiology·S B Dimmitt
Feb 1, 1994·Australian and New Zealand Journal of Medicine·A S Truswell
Feb 9, 2002·Preventive Cardiology·N Goldberg
Feb 8, 2008·Nutrition Reviews·Crystal M RasnakeTherese M Heinonen
Aug 11, 1990·BMJ : British Medical Journal·M F MuldoonK A Matthews
Oct 19, 1991·BMJ : British Medical Journal·L E RamsayP R Jackson
May 22, 1993·BMJ : British Medical Journal·G D SmithT A Sheldon
Apr 29, 1995·BMJ : British Medical Journal·L H LindholmB Scherstén
Jul 13, 1996·BMJ : British Medical Journal·Alberto AscherioW C Willett
Apr 3, 2001·BMJ : British Medical Journal·L HooperS Ebrahim
Sep 29, 2001·The Western Journal of Medicine·M Tanner, N Link
Aug 1, 1994·Journal of Epidemiology and Community Health·G LindbergL Råstam
Aug 17, 1999·Annual Review of Nutrition·S M Grundy
Mar 25, 2011·Annals of Nutrition & Metabolism·Joyce A NettletonGerard Hornstra
Aug 9, 2012·Lipids in Health and Disease·Aline Alves SantanaFabio Santos Lira
Apr 23, 2010·Nutrition & Metabolism·Delfin Rodriguez-Leyva, Grant N Pierce
Aug 10, 2001·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·D K CorlePPT Study Group. Polyp Prevention Trial
Jan 22, 2010·The American Journal of Clinical Nutrition·Patty W Siri-TarinoRonald M Krauss
Feb 13, 2009·The American Journal of Clinical Nutrition·Marianne U JakobsenAlberto Ascherio
Jan 15, 2010·The American Journal of Clinical Nutrition·Patty W Siri-TarinoRonald M Krauss
Dec 31, 2015·International Journal of Food Sciences and Nutrition·Carrie Helen Ruxton
Mar 17, 2015·Critical Reviews in Food Science and Nutrition·Dennis M Bier
May 14, 2016·Nature Reviews. Cardiology·Philip C Calder
Jan 14, 2011·Critical Reviews in Food Science and Nutrition·Alexandra Schmid
May 1, 1994·Annals of Vascular Surgery·W C Krupski
Nov 1, 1995·The Proceedings of the Nutrition Society·I U HaqL E Ramsay
Nov 28, 2006·The American Journal of Cardiology
Mar 11, 2008·Progress in Lipid Research·Arja ErkkiläDavid E Laaksonen
Apr 20, 2000·Psychosomatic Medicine·P H SteegmansD E Grobbee
Apr 5, 2018·International Journal of Food Sciences and Nutrition·Elena Fattore, Elena Massa
Apr 12, 2016·The International Journal of Health Planning and Management·Alison HannGillian Spedding
Jun 13, 2015·The Cochrane Database of Systematic Reviews·Lee HooperGeorge Davey Smith
Jul 19, 2018·The Cochrane Database of Systematic Reviews·Lee HooperKatherine Ho Deane
Jul 19, 2018·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Aug 31, 2006·Circulation·Ignatius G E Zarraga, Ernst R Schwarz
Nov 30, 2018·The Cochrane Database of Systematic Reviews·Lee HooperKatherine Ho Deane
Feb 15, 1992·BMJ : British Medical Journal·George Davey Smith, J Pekkanen
Nov 23, 1991·BMJ : British Medical Journal
Oct 6, 1990·BMJ : British Medical Journal·B Bury
Oct 6, 1990·BMJ : British Medical Journal
Jun 5, 2010·The British Journal of Nutrition·Sébastien CzernichowEric Bruckert
Nov 30, 2005·The Proceedings of the Nutrition Society·Jayne V Woodside, Daan Kromhout
Jul 29, 2005·The Proceedings of the Nutrition Society·J E UpritchardE A Trautwein
May 18, 2012·The Cochrane Database of Systematic Reviews·Lee HooperGeorge Davey Smith
May 16, 2012·Journal of Internal Medicine·W C Willett
Dec 19, 2013·Current Opinion in Lipidology·Michael R FlockPenny M Kris-Etherton
Jun 25, 2017·Annual Review of Nutrition·Dong D Wang, Frank B Hu
Aug 16, 2018·British Journal of Sports Medicine·Zoe Harcombe
May 20, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Jun 4, 2020·The American Journal of Clinical Nutrition·Penny M Kris-Etherton, Ronald M Krauss
May 31, 2007·Journal of the American College of Nutrition·Michael J SheridanCraig E Cheifetz
Aug 23, 2020·The Cochrane Database of Systematic Reviews·Lee HooperAsmaa S Abdelhamid
Jul 24, 2002·Nutrition in Clinical Care : an Official Publication of Tufts University·Marcelo C Batiste, Ernst J Schaefer
Mar 8, 1990·The New England Journal of Medicine
Nov 23, 2017·The Journal of Biological Chemistry·E Madison SullivanSaame Raza Shaikh
Nov 30, 2018·The Cochrane Database of Systematic Reviews·Asmaa S AbdelhamidLee Hooper
Apr 11, 2001·Journal of the American College of Nutrition·F B HuW C Willett
Jan 30, 2002·The American Journal of Clinical Nutrition·Ernst J Schaefer
Nov 16, 2019·Advances in Nutrition·Alice H Lichtenstein
Jul 22, 2020·Current Opinion in Lipidology·Francine K Welty
Dec 30, 2004·Nutrition Reviews·Penny M Kris-EthertonAmy E Binkoski
Sep 6, 2005·The Journal of Cardiovascular Nursing·Jo-Ann Eastwood, Lynn V Doering
Nov 9, 2004·The American Journal of Clinical Nutrition·Dariush MozaffarianDavid M Herrington

Related Concepts

Cardiovascular Diseases
Cholesterol, Dietary
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