Test purchase, synthesis and characterization of 3-fluorophenmetrazine (3-FPM) and differentiation from its ortho- and para-substituted isomers

Drug Testing and Analysis
Gavin McLaughlinSimon D Brandt

Abstract

The knowledge captured in patent and scientific research literature stimulates new ideas and fosters new drug development efforts. Manufacturers and entrepreneurs dedicated to the sale of 'research chemicals' and/or new psychoactive substances (NPS) also make use of access to information to identify, prepare, and launch a range of new substances. One of the most recent compounds to appear on the NPS market is the phenmetrazine analog 3-fluorophenmetrazine (3-FPM) which represents one of many phenylmorpholines designed to explore treatment options in areas such as obesity and drug dependence. The anorectic drug analogs phenmetrazine and phendimetrazine, used as prescription medicines before they were withdrawn, feature amphetamine-like properties associated with monoamine release. Available data on 3-FPM suggest that the effects might show mechanistic overlaps. This study describes the synthesis and extensive analytical characterization of 3-FPM and its differentiation from synthesized ortho- and para- substituted isomers, 2-FPM and 4-FPM, respectively. This study was triggered by the purchase of five powdered samples advertised as 3-FPM by five different Internet vendors based in the United Kingdom. The analytical data obtained...Continue Reading

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Citations

Aug 6, 2016·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Matilda BäckbergAnders Helander
Jan 20, 2017·Drug Testing and Analysis·Simon D Brandt, Pierce V Kavanagh
Apr 22, 2016·Drug Testing and Analysis·Simon D BrandtAdam L Halberstadt
May 8, 2019·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Mamoru Akutsu
Jan 2, 2021·Forensic Science International : Synergy·Nicole S Jones, Jeffrey H Comparin

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