Test-Retest Reliability and Stability of the Nicotine Metabolite Ratio Among Treatment-Seeking Smokers

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Diana A HamiltonLarry W Hawk

Abstract

The nicotine metabolite ratio (NMR), the ratio of 3-hydroxycotinine to cotinine, is a biomarker used in smoking cessation research, with several retrospective studies suggesting that NMR predicts treatment outcome. To be maximally useful in tailoring treatment, estimates of NMR should be stable over time. The present study is the first to examine the short-term test-retest reliability of NMR among treatment-seeking smokers. Blood NMR was assessed at two time points, approximately 2-3 weeks apart and prior to intervention, among 72 healthy adult smokers (49% female; 35% non-White) enrolled in a cessation trial (http://ClinicalTrials.gov ID: NCT01314001). Mean NMR was stable from Time-1 to Time-2, with no significant change between assessments; test-retest reliability for NMR values was excellent (ICC[2,1] = 0.87). Test-retest reliability remained acceptable to high when NMR was categorized, as in recent clinical trials. Classification of participants as slow (quartile 1, NMR ≤ 0.24) or normal/fast NMR (quartiles 2-4, NMR ≥ 0.25) was consistent from Time-1 to Time-2 for 96% of participants (κ = 0.89). Though classification of participants into NMR quartiles was less consistent from Time-1 to Time-2 (67% agreement; weighted κ = 0....Continue Reading

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Citations

Jan 26, 2016·Biological Psychiatry·Mary FalconeCaryn Lerman
Sep 7, 2016·Journal of Pharmaceutical and Biomedical Analysis·Stefano FogliRomano Danesi
Feb 2, 2019·British Journal of Clinical Pharmacology·Stephani L StancilSusan Abdel-Rahman
Mar 11, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Terril L VerplaetseSherry A McKee
Sep 12, 2020·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Jiyeon YangYoungwook Lim
Apr 27, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·James W BaurleyAndrew W Bergen
Feb 14, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Cheyenne E AllenbyMary Falcone

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