Test-retest reliability in an fMRI study of naming in dementia

Brain and Language
Eun Jin PaekDae-Jin Kim

Abstract

fMRI has been used as an outcome measure in dementia treatment studies, with many previous studies comparing only single pre- and post-treatment fMRI scans to determine treatment-induced neural changes, while utilizing single subject experimental designs. The purpose of the current study was to evaluate fMRI test-retest reliability in dementia patients and typical older adults using noun and verb confrontation naming to evaluate the validity of using a single pre/post-treatment scan comparison. Seven individuals with dementia and 9 control participants were tested three times over two months using the same fMRI procedures. Differences in individual and group level activation patterns were observed that varied across time. Additionally, the extent of variability fluctuated across individuals, groups, and the grammatical category of target words. Our findings suggested that one time fMRI scanning may inadequately represent an individual's typical brain activation pattern, particularly an individual with dementia. Thus, multiple imaging baselines are recommended.

References

Dec 1, 1992·Brain : a Journal of Neurology·J R HodgesE Funnell
Sep 1, 1992·Journal of the American Geriatrics Society·E P FeherT H Crook
Jan 1, 1982·Journal of Psychiatric Research·J A YesavageV O Leirer
May 1, 1997·International Journal of Geriatric Psychiatry·P W BenthamJ R Hodges
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·S E PetersenM E Raichle
Dec 9, 1998·Journal of Clinical and Experimental Neuropsychology·R H Benedict, D J Zgaljardic
Apr 19, 2000·Journal of Cognitive Neuroscience·R Cabeza, L Nyberg
Jun 22, 2000·NeuroImage·D J McGonigleA P Holmes
Jul 21, 2000·Journal of the International Neuropsychological Society : JINS·B A WilsonJ J Evans
Dec 2, 2000·Nature Neuroscience·M van TurennoutA Martin
Jun 5, 2001·Acta Psychologica·K G Munhall
Mar 19, 2002·Brain and Language·G J M RuttenC W M van Veelen
Nov 13, 2002·JAMA : the Journal of the American Medical Association·Karlene BallUNKNOWN Advanced Cognitive Training for Independent and Vital Elderly Study Group
Dec 24, 2002·Journal of Cognitive Neuroscience·Michael B MillerMichael S Gazzaniga
Mar 13, 2003·Cerebral Cortex·Miranda van TurennoutAlex Martin
Mar 26, 2003·Journal of Magnetic Resonance Imaging : JMRI·Karsten SpechtLutz Jäncke
Jun 14, 2003·Neuropsychology·Elizabeth A KensingerSuzanne Corkin
Nov 25, 2003·Journal of Cognitive Neuroscience·Michelle LiouChih-Hsin Tsai
Mar 10, 2004·NeuroImage·Xingchang WeiLawrence P Panych
Mar 12, 2004·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Patrick RabbittLynn McInnes
Oct 21, 2004·Alzheimer Disease and Associated Disorders·D B CooperC M Cullum
Mar 25, 2005·The European Journal of Neuroscience·Ingo G MeisterBabak Boroojerdi
Jun 16, 2005·NeuroImage·Torben E LundOlaf B Paulson
Oct 26, 2005·Brain and Language·Per OstbergLars-Olof Wahlund
Oct 27, 2005·Journal of the International Neuropsychological Society : JINS·Ronald F ZecDeb L Larsen
Jun 7, 2006·Brain and Language·E Elinor Chen, Steven L Small
Jun 13, 2006·NeuroImage·Julius FridrikssonGordon Baylis
Feb 9, 2007·Journal of the International Neuropsychological Society : JINS·Mervin BlairAndrew Kertesz
Feb 13, 2007·Neuropsychologia·Julius FridrikssonChris Rorden
Aug 19, 2007·AJNR. American Journal of Neuroradiology·S RauJ Ilmberger
Oct 19, 2007·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jackie MastersonMaureen Hayes
Oct 26, 2007·American Journal of Alzheimer's Disease and Other Dementias·Antoinette E ZehnderAndreas U Monsch
Mar 19, 2008·Seminars in Speech and Language·Sharon M Antonucci, Jamie Reilly

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