Test-retest repeatability of muscle sympathetic nerve activity: influence of data analysis and head-up tilt

Autonomic Neuroscience : Basic & Clinical
Derek S KimmerlyJ Kevin Shoemaker

Abstract

Total integrated muscle sympathetic nerve activity (MSNA) is composed of bursts that vary in both frequency and amplitude. Various quantifiable indices are currently used to characterize MSNA and its reflex-mediated responses. However, a comprehensive and systematic analysis on the test-retest repeatability of these measures has not been conducted. Therefore, the purpose of this study was to compare the consistency of supine and passive head-up tilt-mediated sympathetic nerve activity using different descriptors of MSNA and a statistical paradigm that included Model II ordinary least products (OLP) regression, Bland-Altman method of differences, and analysis of variance. MSNA (microneurography), stroke volume (SV, Doppler), and arterial blood pressure (ABP, Finapres) were measured during repeated supine and 60 degrees head-up tilt (HUT) conditions separated by a minimum of 3 weeks. MSNA was quantified using; burst frequency (and incidence), burst amplitudes (and total integrated activity) normalized to the largest absolute amplitude within each posture, and calculated percent changes (from supine) in absolute burst amplitude and total integrated activity. Most indices of MSNA showed excellent test-retest repeatability during bo...Continue Reading

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Citations

Dec 5, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Marc E GomesCees J Tack
Jan 8, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Seth T FairfaxPaul J Fadel
Jan 28, 2009·Autonomic Neuroscience : Basic & Clinical·Xiaolin YuChong Zhang
Jul 3, 2007·Journal of Cardiac Failure·Austin Chin Chwan NgAndrew Paul Sindone
Aug 1, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·J Kevin ShoemakerDavid F Cechetto
Jun 16, 2011·Clinical Physiology and Functional Imaging·Mikko P TulppoHeikki V Huikuri
Aug 25, 2015·Autonomic Neuroscience : Basic & Clinical·Daniel W WhitePeter B Raven
Feb 13, 2007·NeuroImage·Savio W WongJ Kevin Shoemaker
Dec 8, 2017·Journal of Applied Physiology·Stephen A KlassenJ Kevin Shoemaker
Sep 6, 2017·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J Kevin Shoemaker
Oct 19, 2004·Journal of Applied Physiology·Guy E AlvarezKevin P Davy
Apr 9, 2010·Cognitive Science·David L Gilden
Jul 28, 2009·Physiological Measurement·Tushar P ThakreMichael Smith
Oct 5, 2013·Journal of Applied Physiology·Rebecca P R TompkinsJ Kevin Shoemaker
Mar 24, 2012·Journal of Neurophysiology·Aryan Salmanpour, J Kevin Shoemaker
May 23, 2017·Frontiers in Physiology·Mair ZamirJ Kevin Shoemaker
Sep 25, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ida T Fonkoue, Jason R Carter
Oct 10, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Myles W O'BrienDerek S Kimmerly

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