Testicular biopsy in prepubertal boys: a worthwhile minor surgical procedure?

Nature Reviews. Urology
Alice FaureYves Heloury

Abstract

No consensus exists regarding the precise role of testicular biopsy in prepubertal boys, although it is considered useful for assessing the potential consequences of undescended testes on fertility. Current scientific knowledge indicates that surgeons should broaden indications for this procedure. For example, the use of immunohistochemical markers such as OCT/3-4, TSPY, Kit ligand (SCF) and ALPP (PLAP) has considerably facilitated the detection of germ cell tumour precursors, such as carcinoma in situ and/or gonadoblastoma. These markers are very important for evaluating malignancy risk in undervirilized patients with 46,XY disorders of sexual development. Testicular histology is also of considerable value in the prediction of both fertility potential and risk of cancer in individuals with undescended testes, particularly those with intraabdominal undescended testes. New possibilities for the preservation of fertility after gonadotoxic chemotherapy - even for prepubertal boys - are emerging. Cryopreservation of testicular tissue samples for the preservation of fertility - although still an experimental method at present - is appealing in this context. In our opinion, testicular biopsy in prepubertal boys is a minor procedure t...Continue Reading

References

May 1, 1978·Archives of Andrology·S FuruyaS Sugiyama
Aug 1, 1990·Zeitschrift Für Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Für Kinderchirurgie = Surgery in Infancy and Childhood·D CortesJ Thorup
Feb 1, 1987·International Journal of Andrology·A GiwercmanN E Skakkebaek
Nov 1, 1987·The Journal of Urology·A GiwercmanN E Skakkebaek
Jul 1, 1987·The Journal of Urology·S L MandelbaumA H DeCherney
Sep 9, 1972·Lancet·N E Skakkebaek
Jun 1, 1970·Cancer·R E Scully
Jun 1, 1971·Fertility and Sterility·H Hayashi, R G Harrison
Mar 1, 1969·The Journal of Urology·M J RowleyC G Heller
Jul 1, 1965·Fertility and Sterility·D L GordonC A Paulsen
Jan 1, 1984·Urological Research·F HadziselimovićB Herzog
Nov 1, 1981·The Journal of Pediatrics·F G CassorlaR J Sherins
Jan 1, 1993·European Journal of Pediatrics·D T MininbergS S Witkin
Apr 1, 1994·Urology·W A GourlayW R Nielsen
Dec 1, 1995·Clinical Endocrinology·S G SouleH S Jacobs
Sep 11, 1998·BMJ : British Medical Journal·H MøllerJ Thorup
Jan 29, 1999·Endocrinology and Metabolism Clinics of North America·S Howell, S Shalet
May 13, 1999·Molecular Endocrinology·S ZimmermannI M Adham
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·K P Dieckmann, N E Skakkebaek
Aug 25, 2000·The Journal of Urology·D A DiamondA B Retik
Jan 6, 2001·Scandinavian Journal of Urology and Nephrology. Supplementum·M RørthN E Skakkebaek
Dec 18, 2001·The Journal of Urology·Richard A SchoorLawrence S Ross
May 4, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·Olaf Hiort
Aug 7, 2002·Journal of Animal Science·J M OatleyJ J Reeves
Dec 13, 2002·Fertility and Sterility·Makoto NaganoRalph L Brinster
May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Dina CortesJakob Visfeldt
Jun 11, 2003·The Journal of Urology·Eric HuyghePatrick Thonneau
Feb 1, 1960·The Journal of Clinical Endocrinology and Metabolism·F A DE LA BALZEO W DAVIDSON
Nov 25, 2003·The Journal of Urology·Julia Spencer Barthold, Ricardo González
Dec 6, 2003·Molecular and Cellular Endocrinology·J GuibourdencheM Noël
Jul 24, 2004·International Journal of Andrology·Niels E Skakkebaek
Aug 21, 2004·Human Reproduction Update·Herman TournayeAndré Van Steirteghem
Mar 2, 2005·Nature Reviews. Cancer·J Wolter Oosterhuis, Leendert H J Looijenga
Apr 7, 2005·The Lancet Oncology·W Hamish B WallaceD Stewart Irvine
Apr 12, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C E Hoei-HansenN E Skakkebaek
Jul 13, 2005·European Urology·Klaus-Peter DieckmannUNKNOWN German Testicular Cancer Study Group
Oct 8, 2005·Human Reproduction·K KvistC Yding Andersen
Jan 10, 2006·The Journal of Pathology·S E HannemaI A Hughes
Apr 21, 2006·Archives of Disease in Childhood·I A HughesUNKNOWN ESPE Consensus Group
Jun 1, 2006·Endocrine Reviews·Martine CoolsLeendert H J Looijenga

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Citations

Jun 23, 2016·Future Oncology·Miyuki Harada, Yutaka Osuga
Feb 28, 2017·Journal of Pediatric Urology·Nicole MennieChris Kimber
Jan 28, 2019·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Jorgen Thorup, Dina Cortes
Apr 14, 2020·Biopreservation and Biobanking·Andréia Maria da SilvaAlexandre Rodrigues Silva
May 5, 2020·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Arati A InamdarWendy Shertz
Jun 3, 2021·Animals : an Open Access Journal From MDPI·Tomislav ŠušnjarZenon Pogorelić
Oct 13, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A SantaballaD Manau-Trullas

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