Testicular cytotoxicity of intravenous doxorubicin in rats

The Journal of Urology
R C LuiF E Johnson

Abstract

Although the testicular cytotoxicity of many chemotherapeutic drugs has been evaluated in mice, their small size can pose technical problems. In this report, we describe doxorubicin-induced testicular toxicity in a larger animal model, the Sprague-Dawley rat. Fifty-three rats were used for this study. On day 0, rats in the treatment groups were anesthetized and given different single intravenous doses of doxorubicin (0.1 to 30 mg./kg.). On day 56 +/- 2, all surviving rats were killed and necropsied. Testicular toxicity was evaluated qualitatively by histology and quantitatively by testicular weight, sperm head count, repopulation index and epididymal index. The histologic effects of doxorubicin on the heart, liver and kidney were qualitatively evaluated. Progressive dose-dependent testicular atrophy and oligospermia occurred at low and intermediate dosages of doxorubicin (0.1 to 5 mg./kg.). Marked testicular atrophy, oligospermia and germinal aplasia were observed at high dosage of doxorubicin (10 mg./kg.). LD50 for animal mortality at day 56 +/- 2 for doxorubicin appears to be 10 mg./kg. These findings are similar to those reported in mice. The rat is a suitable model for the study of techniques to avoid drug-induced testicula...Continue Reading

References

Jun 1, 1978·Australian and New Zealand Journal of Medicine·H P RoeserA J Smith
Jul 1, 1969·Fertility and Sterility·E Steinberger, D Y Tjioe
Aug 1, 1966·Mutation Research·B M Cattanach
Jul 1, 1980·Annals of Internal Medicine·R L SchilskyR C Young
Jun 1, 1974·British Journal of Clinical Pharmacology·P M Wilkinson, G E Mawer

❮ Previous
Next ❯

Citations

Dec 1, 1988·Journal of Surgical Oncology·R C LuiF E Johnson
Apr 17, 2015·Journal of Assisted Reproduction and Genetics·Jun HagiudaKen Nakagawa
Jun 1, 2016·Toxicology Research·Oluwajoba O AkinjoEmma L Marczylo
Nov 1, 1988·Clinical and Experimental Pharmacology & Physiology·R N Nwankwoala, W L West
Mar 1, 1994·Journal of Surgical Oncology·F E JohnsonY C Woo
Oct 31, 2012·The Journal of Obstetrics and Gynaecology Research·Reiko TanigakiYasunori Yoshimura
Feb 18, 2003·International Journal of Urology : Official Journal of the Japanese Urological Association·Fumiyasu EndoHideyuki Akaza
May 28, 2010·Journal of Assisted Reproduction and Genetics·Kenji SatoYoshihiko Hosoi
Jul 20, 2002·Reproductive Toxicology·Jong- Koo KangSang- Yoon Nam
Apr 6, 2005·Reproductive Toxicology·Chidambaram PrahalathanPalaninathan Varalakshmi
Jan 26, 2006·Chemico-biological Interactions·Chidambaram PrahalathanPalaninathan Varalakshmi
Aug 23, 2005·Reproductive Toxicology·Chidambaram PrahalathanPalaninathan Varalakshmi
Jun 21, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Chidambaram PrahalathanPalaninathan Varalakshmi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.