Testicular Degeneration and Infertility following Arbovirus Infection.

Journal of Virology
Giantonella PuggioniCiriaco Ligios

Abstract

Arboviruses can cause a variety of clinical signs, including febrile illness, arthritis, encephalitis, and hemorrhagic fever. The recent Zika epidemic highlighted the possibility that arboviruses may also negatively affect the male reproductive tract. In this study, we focused on bluetongue virus (BTV), the causative agent of bluetongue and one of the major arboviruses of ruminants. We show that rams that recovered from bluetongue displayed signs of testicular degeneration and azoospermia up to 100 days after the initial infection. Importantly, testicular degeneration was induced in rams experimentally infected with either a high (BTV-1IT2006)- or a low (BTV-1IT2013)-virulence strain of BTV. Rams infected with the low-virulence BTV strain displayed testicular lesions in the absence of other major clinical signs. Testicular lesions in BTV-infected rams were due to viral replication in the endothelial cells of the peritubular areas of the testes, resulting in stimulation of a type I interferon response, reduction of testosterone biosynthesis by Leydig cells and destruction of Sertoli cells and the blood-testis barrier in more severe cases. Hence, BTV induces testicular degeneration and disruption of spermatogenesis by replicating...Continue Reading

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Citations

Feb 8, 2020·Physiological Reviews·Anna Le TortorecNathalie Dejucq-Rainsford
Jun 25, 2020·Andrologia·Rahul Vishvkarma, Singh Rajender
Jul 30, 2019·Frontiers in Immunology·Haruki Arévalo RomeroMoises León Juárez
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Sep 23, 2020·Andrology·Chuan HuangWenbing Zhu
Oct 3, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Olugbemi T OlaniyanOlugbenga O Eweoya
Jan 21, 2021·The Journal of Sexual Medicine·Mustafa KadihasanogluAtes Kadioglu
May 13, 2021·Journal of Assisted Reproduction and Genetics·Mojgan MoshrefiMohammad Ali Khalili
Jun 29, 2021·Zygote : the Biology of Gametes and Early Embryos·Amirreza Niazi TabarHossein Azizi
Jun 29, 2021·Middle East Fertility Society Journal·Koushik BhattacharyaAlak Kumar Syamal

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Methods Mentioned

BETA
Confocal microscopy
Confocal
SMA
enzyme-linked immunosorbent assay
reverse transcription-PCR
transgenic
ELISA

Software Mentioned

Zen
Sequence Detection Systems

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