Testicular dysgenesis syndrome and the origin of carcinoma in situ testis

International Journal of Andrology
Si Brask SonneHenrik Leffers

Abstract

Recent increases in male reproductive disorders have been linked to exposure to environmental factors leading to the testicular dysgenesis syndrome (TDS). Testicular cancer is the most severe condition in TDS and studies have shown a clear correlation between risk of testicular cancer and other components of TDS and that the geographical location of the mother during pregnancy can be a risk factor. This suggests that the dysgenesis has its origin in utero and that TDS is initiated by environmental factors, including possibly hormone-disrupting compounds that act on the mother and the developing foetus, but the genetic background may also play a role. The morphological similarity of carcinoma in situ (CIS) cells (the precursor of the majority of invasive testicular cancers) with primordial germ cells and gonocytes, and overlap in expression of protein markers suggests an origin of CIS from primordial germ cells or gonocytes. CIS cells and germ cell-derived cancers of the human type have so far not been described in any animal model of TDS, which could be caused by species differences in the development of the male gonad. Regardless of this, it is plausible that the dysgenesis, and hence the development of CIS cells, is a result ...Continue Reading

References

Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Aug 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A GiwercmanN E Skakkebaek
Mar 1, 1985·The Journal of Pediatrics·J MüllerK E Petersen
Sep 9, 1972·Lancet·N E Skakkebaek
Jan 1, 1974·Virchows Archiv. A, Pathological Anatomy and Histology·A F Holstein, F Körner
Mar 1, 1982·Cancer·M A BatataR B Golbey
Oct 1, 1983·Cancer Genetics and Cytogenetics·N B Atkin, M C Baker
Jul 20, 1994·Journal of the National Cancer Institute·R J van GurpL H Looijenga
Jan 1, 1996·Epidemiology·A PrenerO M Jensen
Jan 14, 1998·Cancer Causes & Control : CCC·H Møller, N E Skakkebaek
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·N E SkakkebaekJ Müller
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P M PetersenA Giwercman
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H Møller
Nov 14, 1998·Seminars in Cell & Developmental Biology·M Bendel-StenzelC Wylie
Feb 26, 1999·BMJ : British Medical Journal·H Møller, N E Skakkebaek
Apr 9, 1999·International Journal of Andrology·D N Veeramachaneni, S Vandewoude
Feb 3, 2000·Human Reproduction·A G AndersenN E Skakkebaek
Jan 6, 2001·Scandinavian Journal of Urology and Nephrology. Supplementum·M RørthN E Skakkebaek
Feb 19, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Anne-Marie ZeemanLeendert H J Looijenga
Mar 28, 2002·The Journal of Toxicological Sciences·Kaori MiyataMasatoshi Matsuo
Apr 30, 2002·International Journal of Cancer. Journal International Du Cancer·Kari HemminkiKamila Czene
Apr 30, 2002·International Journal of Cancer. Journal International Du Cancer·Kari Hemminki, Xinjun Li
Apr 30, 2002·Genes, Chromosomes & Cancer·Sigrid Marie KraggerudRagnhild A Lothe
May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Niels E SkakkebaekEwa Rajpert-De Meyts
May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ewa Rajpert-De MeytsNiels E Skakkebaek
Jan 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Karel De GendtGuido Verhoeven
Mar 25, 2004·Molecular Reproduction and Development·Eihachiro KawaseRoger A Pedersen

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Citations

May 12, 2010·Expert Reviews in Molecular Medicine·Roopa L Nalam, Martin M Matzuk
May 16, 2009·Human Reproduction·Olof Akre, Lorenzo Richiardi
Nov 26, 2009·Human Reproduction·Michael Joffe
Sep 29, 2012·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·A P WalkerP M G Bouloux
Jun 11, 2010·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Michael C Risk, Timothy A Masterson
Jul 17, 2008·European Journal of Endocrinology·Pierre D E Mouriquand
Sep 20, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·S S Jeetle, D M Berney
Jul 9, 2010·Seminars in Pediatric Surgery·John M HutsonBridget Southwell
Mar 1, 2009·Surgical Pathology Clinics·Tehmina Z Ali, Anil V Parwani
Mar 24, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Gert-Jan M van de GeijnLeendert H J Looijenga
Jul 28, 2011·International Journal of Andrology·J W OosterhuisL H J Looijenga
Sep 17, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jessica LaRoccaMary Hixon
Dec 6, 2011·Molecular and Cellular Endocrinology·Angelina WallacidesHéène Dumond
Aug 3, 2010·Early Human Development·Simone FunkeTibor Ertl
Jun 15, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Leendert H J LooijengaKatja P Wolffenbuttel
Jul 30, 2014·Seminars in Cancer Biology·Martin A Rijlaarsdam, Leendert H J Looijenga
Nov 13, 2015·Biology of Reproduction·Jonathan T Busada, Christopher B Geyer
Feb 9, 2018·Oncotarget·Gaetano FacchiniMicaela Montanari
May 18, 2021·Asian Journal of Urology·Melanie R MüllerDaniel Nettersheim

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