Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis

International Journal of Andrology
Niels JørgensenN E Skakkebaek

Abstract

In 2001, when the testicular dysgenesis syndrome (TDS) concept was proposed, it suggested that impaired development of foetal testes could lead to increased risks of cryptorchidism, hypospadias, decreased spermatogenesis or testis cancer. The TDS concept links the pathogenesis of the four disorders together, but does not imply that all affected men develop all four symptoms. The least affected men may merely have a slightly reduced spermatogenic capacity, and only the most severely affected may present all symptoms. A majority of cases of testicular germ cell cancers (TGCC) and cryptorchidism are most likely caused by TDS. However, the frequency of the syndrome in the general population and to what extent poor semen quality and hypospadias are actually biologically related through a foetal mechanism remain unresolved. Hypospadias and impaired spermatogenesis can be classified as TDS if combined with cryptorchidism or TGCC. By contrast, recent studies demonstrated that among men with isolated hypospadias, only a fraction of cases are linked to TDS. There is no doubt that TDS contributes to impaired semen quality. This is most obvious for cases with visible dysgenetic features in testis histology, but in the majority of men with ...Continue Reading

References

Aug 1, 1987·International Journal of Andrology·D CortesN E Skakkebaek
Sep 9, 1972·Lancet·N E Skakkebaek
Jan 17, 2002·The New England Journal of Medicine·D S GuzickUNKNOWN National Cooperative Reproductive Medicine Network
May 20, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Niels E SkakkebaekEwa Rajpert-De Meyts
May 30, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·Richard M SharpeJane S Fisher
Jun 29, 2004·The Journal of Pathology·Friedemann HoneckerLeendert H J Looijenga
May 28, 2005·Human Reproduction·M S JensenJ P Bonde
Aug 5, 2005·Environmental Health Perspectives·Shanna H SwanUNKNOWN Study for Future Families Research Team
Sep 1, 2005·The Journal of Clinical Endocrinology and Metabolism·Rodolfo A ReyFernando G Cassorla
Jan 6, 2006·The Journal of Clinical Endocrinology and Metabolism·Anne-Maarit SuomiJorma Toppari
Feb 10, 2006·International Journal of Andrology·Niels JørgensenNiels E Skakkebaek
Apr 6, 2006·The Journal of Clinical Endocrinology and Metabolism·Katharina M MainNiels E Skakkebaek
Sep 28, 2006·Hormones : International Journal of Endocrinology and Metabolism·Marko Kaleva, Jorma Toppari
Mar 1, 2007·Acta Paediatrica·E Martin RitzénH Virtanen
Apr 28, 2007·Acta Paediatrica·Helena E VirtanenKatharina M Main
Jun 6, 2007·Clinical Endocrinology·Martine CoolsLeendert H J Looijenga
Sep 6, 2007·Molecular Human Reproduction·Isabella GashawElke Winterhager
Jan 5, 2008·Environmental Health Perspectives·Ulla HassAndreas Kortenkamp
Feb 6, 2008·International Journal of Andrology·Andreas Kortenkamp
Feb 19, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Ieuan A Hughes
Mar 5, 2008·International Journal of Andrology·S ChristiansenU Hass
Apr 19, 2008·Current Urology Reports·Michael H HsiehLaurence S Baskin
May 24, 2008·Journal of Andrology·Ming-Hsien Wang, Laurence S Baskin
Jun 27, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Richard M Sharpe
Jul 19, 2008·International Journal of Andrology·Nicolas KalfaCharles Sultan
Sep 25, 2008·Clinical Endocrinology·Berenice Bilharinho MendoncaElaine M F Costa
Oct 25, 2008·Journal of Pediatric Urology·Laurence S Baskin
Mar 14, 2009·International Journal of Andrology·C AsklundN Jørgensen
May 16, 2009·Human Reproduction·Olof Akre, Lorenzo Richiardi
Jun 18, 2009·The Journal of Clinical Endocrinology and Metabolism·Bertrand IsidorCédric Le Caignec

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Citations

Mar 1, 2012·Human Reproduction Update·L F M van der ZandenN Roeleveld
Dec 20, 2011·Asian Journal of Andrology·Robert Oates
Nov 3, 2010·Asian Journal of Andrology·Rafael Oliva, Judit Castillo
Sep 28, 2015·Seminars in Cell & Developmental Biology·Anne JørgensenEwa Rajpert-De Meyts
Mar 4, 2011·International Journal of Andrology·N JørgensenJ Toppari
Feb 22, 2011·International Journal of Andrology·M F FernandezN Jørgensen
Jan 12, 2013·Andrology·Jaime MendiolaAlberto M Torres-Cantero
Jun 15, 2011·International Journal of Andrology·M B CookK A McGlynn
Jul 9, 2014·Orvosi hetilap·László SágodiLászló Barkai
Jun 18, 2014·Orvosi hetilap·László SágodiLászló Barkai
Aug 12, 2014·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Manuel NistalMiguel Reyes-Múgica
Jun 26, 2001·Journal of the American Academy of Dermatology·D Ben-AmitaiA Metzker
Mar 16, 2011·Nature Reviews. Urology·Katrine BayNiels E Skakkebæk
Feb 28, 2018·BMC Veterinary Research·Giovanna LiguoriNicola Mirabella
Nov 7, 2019·Andrology·UNKNOWN Cairo Consensus Workshop Group
Jun 24, 2020·The Journal of Clinical Endocrinology and Metabolism·Margit Bistrup FischerAnders Juul
Jul 11, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Ismail SelviHalil Basar
Jul 20, 2020·Andrology·Daniel Moreno-MendozaCsilla Krausz
Jul 20, 2021·International Journal of Urology : Official Journal of the Japanese Urological Association·Shinichi YamashitaYoichi Arai

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