PMID: 9165472May 1, 1997Paper

Testicular enlargement in patients with 11-hydroxylase deficiency

Journal of Pediatric Surgery
I KarnakA Hiçsönmez

Abstract

Testicular nodules or tumors have been well described in patients with congenital adrenal hyperplasia (CAH) and usually associated with 21-hydroxylase deficiency. The authors report on a 11-hydroxylase--deficient patient presenting bilateral testicular enlargement and review the literature. Testicular biopsy was not very helpful to make differential diagnosis between adrenal rest hyperplasia and Leydig cell tumor. The size of testes regressed after steroid replacement therapy, and this observation was suggestive for adrenal rest hyperplasia. These findings suggest that bilateral testicular enlargement in patients with CAH may occur after excessive adrenocorticotrophic hormone stimulation of cells differentiated from unknown origin. Orchiectomy is not required but bilateral testicular biopsy must be performed.

References

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Citations

Sep 24, 2005·Pediatric Surgery International·Tuğrul TiryakiHalil Atayurt
Jan 5, 2011·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Ahmed IntezarShiv N Kureel
Dec 7, 2013·Urology Annals·M Ezzedien RabieMubarak M Al-Shraim
Feb 19, 2014·European Journal of Endocrinology·Seher PolatFelix G Riepe
Oct 20, 2006·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Suat FitozGonul Ocal
Sep 14, 2000·The Urologic Clinics of North America·M A Rich, M A Keating
Sep 14, 2006·Clinical Pediatrics·C Gerry HendersonRichard H Schwartz
Feb 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Virginia Oliveira FernandesRenan Magalhães Montenegro
Oct 1, 2020·Computational and Structural Biotechnology Journal·Mengling Ye, Ye Chen
Jun 2, 2007·Journal de radiologie·M RibagnacO Rouvière

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