Testicular germ-cell cancer

Lancet
Alan HorwichRobert Huddart

Abstract

Testicular germ-cell tumours (TGCTs) represent the model of a curable malignancy; sensitive tumour markers, accurate prognostic classification, logical series of management trials, and high cure rates in both seminomas and non-seminomas have enabled a framework of effective cancer therapy. Understanding the molecular biology of TGCT could help improve treatment of other cancers. The typical presentation in young adults means that issues of long-term toxicity become especially important in judging appropriate management. A focus of recent developments has been to tailor aggressiveness of treatment to the severity of the prognosis. Recent changes affect the most common subtypes and include the reduction of chemotherapy for patients who have metastastic non-seminomas and a good prognosis, and alternatives to adjuvant radiotherapy in stage I seminomas. We summarise advances in the understanding and management of TGCT during the past decade.

References

Jun 4, 1987·The New England Journal of Medicine·S D WilliamsP J Loehrer
Apr 15, 1985·Cancer·D J TollerudK O'Connell
Aug 1, 1985·Journal of Neurosurgery·M T JenningsF Hochberg
Jul 15, 1984·International Journal of Cancer. Journal International Du Cancer·J W OosterhuisI Damjanov
Apr 1, 1981·Cancer Genetics and Cytogenetics·N B Atkin, M C Baker
Apr 1, 1994·International Journal of Andrology·E Rajpert-De Meyts, N E Skakkebaek
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W F Hendry
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H LampeA Horwich
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J Hughes, S B Kaye
Jul 1, 1993·Environmental Health Perspectives·A GiwercmanN E Skakkebaek
Apr 30, 1994·International Journal of Radiation Oncology, Biology, Physics·R T OliverW R Pratt
Mar 1, 1994·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A Horwich, J Bell
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J P DrozJ L Pico
Jan 21, 1993·International Journal of Cancer. Journal International Du Cancer·J R MastersC N Parris
Jun 1, 1996·Virchows Archiv : an International Journal of Pathology·E Rajpert-De MeytsN E Skakkebaek
Jun 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J R MastersH Lohrer
Jan 1, 1996·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C BokemeyerH J Schmoll
May 1, 1997·Cancer Genetics and Cytogenetics·B de JongJ W Oosterhuis
May 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G M DuchesneP A Cook
Nov 5, 1997·Journal of the National Cancer Institute·L B TravisJ D Boice
Jul 2, 1998·Seminars in Urologic Oncology·J P DonohueP Tognoni
Sep 2, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·O HenegariuN A Heerema
Dec 17, 1998·International Journal of Urology : Official Journal of the Japanese Urological Association·N ShinoharaT Koyanagi
Feb 17, 1999·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·B SummersgillJ Shipley
Jun 11, 1999·The American Journal of Pathology·Q TianC A Moskaluk
Mar 10, 2000·International Journal of Cancer. Journal International Du Cancer·C MeijerN H Mulder
Jun 15, 2000·European Journal of Nuclear Medicine·S F HainR A Huddart
Sep 14, 2000·The Urologic Clinics of North America·H S Levin
Sep 29, 2000·BMJ : British Medical Journal·R JacobsenH Moller
Oct 6, 2000·The American Journal of Pathology·H RoelofsL H Looijenga

❮ Previous
Next ❯

Citations

Aug 28, 2013·Der Urologe. Ausg. A·F ZengerlingM Schrader
Aug 3, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rui ZhuAngabin Matin
Dec 1, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Shirley HammondAngabin Matin
Aug 31, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Uros BumbasirevicCane Tulic
Jul 11, 2007·Hernia : the Journal of Hernias and Abdominal Wall Surgery·C CostopoulosN Bullock
Sep 14, 2011·Reviews in Endocrine & Metabolic Disorders·Livio CasariniManuela Simoni
Sep 18, 2007·Stem Cell Reviews·Amander T Clark
Dec 16, 2006·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·E VilarJ Tabernero
Dec 27, 2011·Cancer Letters·Carmen Jerónimo, Rui Henrique
Oct 1, 2013·Expert Reviews in Molecular Medicine·R KosterS de Jong
May 7, 2010·Journal of the American Chemical Society·Wee Han AngStephen J Lippard
Aug 11, 2012·Journal of Medicinal Chemistry·Chee Fei ChinWee Han Ang
Dec 15, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Asli YilmazKiril Trpkov
Nov 3, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daniel M BerneyR Timothy D Oliver
Dec 5, 2008·Nature·Elsa QuintanaSean J Morrison
Jun 15, 2010·Nature Genetics·Clare TurnbullUNKNOWN UK Testicular Cancer Collaboration
Mar 18, 2011·Nature Reviews. Cancer·Duncan GilbertJanet Shipley
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Patrick SchmidtHinrich Abken
Jul 16, 2010·Journal of the National Cancer Institute·Peter S GrimisonGuy C Toner
Jun 21, 2011·The Nurse Practitioner·Barbara H Zoltick
Oct 13, 2012·Anti-cancer Drugs·Vincenzo GigantinoGaetano Facchini
Apr 7, 2007·Current Opinion in Oncology·Benjamin Bridges, Arif Hussain
Oct 30, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·S A Sohaib, J Husband
Jan 5, 2007·Onkologie·Alan Horwich
Sep 3, 2010·The Journal of Clinical Investigation·Roelof KosterSteven de Jong
Oct 17, 2012·BMC Clinical Pathology·Felix BremmerCarl Ludwig Behnes
Mar 16, 2007·World Journal of Surgical Oncology·Roderich E Schwarz
Mar 25, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Clare MoynihanAlan Horwich
Apr 20, 2013·PLoS Genetics·Sander G BastenRachel H Giles
Jul 24, 2008·AJR. American Journal of Roentgenology·S Aslam SohaibJanet E Husband
Jun 11, 2010·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Emma J AlexanderAlan Horwich
Feb 4, 2014·Virchows Archiv : an International Journal of Pathology·Leendert H J LooijengaKatharina Biermann
Sep 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J AparicioJ R Germà
Mar 15, 2013·Journal of Clinical Pathology·Michal MegoJozef Mardiak

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