Testicular histopathology as a predictor of a positive sperm retrieval in men with non-obstructive azoospermia

BJU International
Amr Abdel RaheemDavid Ralph

Abstract

WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The management of patients with non-obstructive azoospermia (NOA) involves testicular sperm extraction (TESE or microdissection TESE) combined with intracytoplasmic sperm injection (ICSI). Sperm retrieval is successful in up to 50% of men with NOA; however, there is no single clinical finding or investigation that can accurately predict a positive outcome. Several studies have concluded that testicular biopsy is the best predictor of a successful TESE. The present study shows that the strongest predictor of the success of TESE is when tubules with mature spermatozoa (Johnsen score ≥8) are found in the histopathology specimen, irrespective of the overall state of spermatogenesis. The findings suggest that a lower limit threshold value of 2% of tubules with spermatogenesis in the histopathology specimen will result in a positive sperm retrieval. However, it is not practical to perform a diagnostic biopsy before TESE because this would mean that patients undergo two surgeries, which adds to the cost and increases the complications. The diagnostic biopsy is best coupled with an initial TESE before starting the ICSI cycle. Based on the findings of the histopathology specimen...Continue Reading

Associated Clinical Trials

May 9, 2017·Mohammad Abbass

References

Jul 1, 1989·The Journal of Urology·J P JarowL I Lipshultz
Jan 1, 1989·European Urology·P J Patel, S S Pareek
Jul 1, 1982·Forensic Science International : Synergy·G M Willott
Aug 1, 1997·Human Reproduction·P N Schlegel, L M Su
Jul 1, 1998·Human Reproduction·B RosenlundT Hillensjö
Oct 2, 1998·Human Reproduction·J TesarikC Mendoza
Jan 10, 2001·Current Opinion in Urology·P T Chan, P N Schlegel
Dec 18, 2001·The Journal of Urology·Richard A SchoorLawrence S Ross
Feb 18, 2004·Fertility and Sterility·Joseph Har-ToovAriel J Jaffa
Mar 23, 2004·World Journal of Urology·K-P Dieckmann, U Pichlmeier

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Citations

Sep 10, 2013·Fertility and Sterility·Agnieszka MalcherMaciej Kurpisz
Nov 30, 2013·The Urologic Clinics of North America·Boback M Berookhim, Peter N Schlegel
Feb 19, 2015·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·T AydinF Tokat
Dec 3, 2014·Fertility and Sterility·Boback M BerookhimPeter N Schlegel
May 5, 2016·Seminars in Cell & Developmental Biology·Filipe Tenorio Lira NetoMarc Goldstein
May 14, 2016·BMC Urology·Giorgio FrancoErmanno Greco
May 3, 2016·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Rosa Alice Casemiro MonteiroJorge Hallak
Aug 31, 2018·Andrologia·Anne-Laure BarbotinValerie Mitchell
Feb 1, 2019·International Urology and Nephrology·Medhat Kamel AmerSameh Fayek GamalEl Din
Apr 19, 2019·Human & Experimental Toxicology·N P de SouzaM G Nascimento E Pontes
Oct 31, 2019·Human Reproduction Update·Giovanni CoronaNikolaos Sofikitis
Apr 22, 2017·Clinical and Experimental Reproductive Medicine·Peyman SalehiMansour Salehi
Jun 11, 2020·International Urology and Nephrology·Muhammad A ArshadSandro C Esteves
Jan 1, 2013·Basic and Clinical Andrology·Aaron M BerniePeter N Schlegel
Feb 23, 2017·Journal of Endocrinological Investigation·D TsitlakidisA Kritis
Nov 6, 2018·Scientific Reports·Muhammad Jaseem KhanAlexander N Yatsenko
Jul 25, 2019·Basic and Clinical Andrology·Amin BoukerSalima Fourati
Mar 8, 2014·Reproductive Medicine and Biology·Satoru KantoTeruaki Iwamoto

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