Dec 1, 1975

Testicular inhibition of fetal Mullerian ducts in vitro: effect of dibutyryl cyclic AMP

Molecular and Cellular Endocrinology
R Picon


The effect of dibutyryl cyclic AMP (dibutyryl cAMP) on Mullerian ducts of 141/2-day-old rat fetuses in vitro was investigated. Dibutyryl cAMP was unable to produce the typical regression of Müllerian ducts which is observed in vivo in male fetuses and in vitro with Müllerian ducts in the presence of testes. Effects of dibutyryl cAMP and theophylline on regeneration of Müllerian ducts induced by fetal testes were also investigated, and it was found that 10(-3) dibutyryl cAMP added to the culture medium prevented the normal regression. Lower concentrations and theophyline (10(-3)M) were ineffective. An effect of lower doses of dibutyryl cAMP was obtained only when theophylline was also present. Because pretreatment of testes with dibutyryl cAMP did not prevent the inhibiting action of testes on Müllerian ducts, it is concluded that an interaction between dibutyryl cAMP and the inhibiting factor at the level of the target organs must be considered.

Mentioned in this Paper

Structure of Paramesonephric Duct
Bucladesine, Barium (1: 1) Salt

About this Paper

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Meningococcal Myelitis

Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.