Testicular microanatomical and hormonal alterations following use of antiretroviral therapy in Sprague Dawley rats: Role of Naringenin

Andrologia
M Y AdanaO O Azu

Abstract

Human immunodeficiency virus-infected man may require assisted reproductive technology not just for safer conception but also due to subfertility. The study investigated the effect of antiretroviral drugs on the fertility potentials of males and the possible protective role of Naringenin, using Sprague Dawley rats. Thirty adult male Sprague Dawley rats were grouped into-A: Distilled water; B: Highly Active Antiretroviral Therapy (HAART); C: Naringenin 40 mg/kg; D: Naringenin 80 mg/kg, E: HAART + Naringenin 40 mg/kg; F: HAART + Naringenin 80 mg/kg. The rats were euthanised after 10 weeks. Results showed a significant decrease in sperm count in group B when compared to the control and other groups. Spermatozoa with normal morphology also reduced significantly in the B group and progressive sperm motility reduced when compared to the control, D and the F group. The serum testosterone was not significantly different between groups A and B, however the groups C and D displayed significant increase when compared to groups A and B. The serum luteinising hormone was significantly higher in group B when compared to groups A, E and F. Our data suggest that Naringenin improves the male reproductive anatomy and function, therefore, it prom...Continue Reading

References

Feb 1, 1990·American Journal of Clinical Pathology·M da SilvaH L Ioachim
Nov 30, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·C FelginesC Rémésy
May 1, 1964·The Anatomical Record·A D CHIQUOINE
Oct 4, 2003·Nature Reviews. Drug Discovery·William LewisWilliam C Copeland
Oct 7, 2003·European Journal of Drug Metabolism and Pharmacokinetics·Ritu AnejaRamesh Chandra
Jun 21, 2007·Reproductive Biomedicine Online·R John Aitken, Geoffry N De Iuliis
Mar 5, 2008·AIDS·Elisabeth van LeeuwenJan M Prins
May 7, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·James KebleshHuangui Xiong
Dec 10, 2008·Toxicology·J Renugadevi, S Milton Prabu
Apr 3, 2009·The New England Journal of Medicine·Mari M KitahataUNKNOWN NA-ACCORD Investigators
Jun 2, 2009·Fertility and Sterility·Georgina M ChambersG David Adamson
Oct 2, 2009·Oxidative Medicine and Cellular Longevity·R John Aitken, Shaun D Roman
Jan 1, 2009·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Mohammed RahmatullahWahid Mozammel Haque
Mar 31, 2011·Archives of Gynecology and Obstetrics·Sven KehlMarc Sütterlin
Nov 18, 2011·AIDS·Fumiyo NakagawaAndrew N Phillips
Dec 17, 2011·PloS One·Vincenzo RochiraGiovanni Guaraldi
May 12, 2012·Oxidative Medicine and Cellular Longevity·Milan CizAntonin Lojek
Feb 12, 2013·American Journal of Obstetrics and Gynecology·Augusto Enrico SempriniDenise J Jamieson
Jul 13, 2013·Chemico-biological Interactions·Anca HermeneanAnca Dinischiotu
Mar 19, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Rong Chang ChenXiao Bo Sun
Apr 19, 2015·Reproductive Biology and Endocrinology : RB&E·Hasmik MargaryanJana Peknicova
May 7, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Xiang ChenLei Chen
Jul 1, 2015·Archives of Pathology & Laboratory Medicine·Kurt FisherRomil Saxena
Oct 20, 2015·Cell Stress & Chaperones·Intidhar Ben SalemSalwa Abid Essefi
Jan 6, 2016·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Karen Augustine-RauchJulieta M Panzica-Kelly
Jun 13, 2016·Tissue & Cell·Gamal Said Abd El-AzizRaid Mahmoud Hamdy
Nov 8, 2016·Toxicological Research·Oluwatosin O OgedengbeOnyemaechi O Azu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.