Testicular pathologic changes and the pituitary-testicular axis during human immunodeficiency virus infection.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
B SalehianJ A McCutchan

Abstract

To chronicle pituitary-testicular axis dysfunction and its clinicopathologic features in homosexual men. Between 1984 and 1992, 84 homosexual men underwent longitudinal follow-up for 4 years. At entry into the study, 28 were seronegative and 56 were seropositive for human immunodeficiency virus (HIV). Although 40 subjects remained asymptomatic (nonprogressors), 16 had progression to acquired immunodeficiency syndrome (AIDS). Of those 16 patients with progression, 8 had AIDS within 2 years (early progressors) and 8 demonstrated AIDS within 4 years after enrollment (late progressors), and all died. The testes of five patients were examined at autopsy. The control group had similar follow-up. Luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and bioavailable testosterone (bio-T) were measured in stored sera collected at 2-year intervals. The last hormonal measurement was between 3 and 24 months before autopsy. Comparison was made between autopsied and nonautopsied patients with AIDS as well as between HIV nonprogressors and control seronegative men. The correlation between pathologic findings and hormonal status was examined by regression analysis. At baseline, testosterone, bio-T, LH, and FSH were not si...Continue Reading

References

Jul 1, 1975·The Journal of Clinical Endocrinology and Metabolism·S R SmithC J Migeon
Feb 1, 1991·The American Journal of Clinical Nutrition·J C MelchiorM Apfelbaum
Feb 1, 1991·Endocrine Reviews·M K Skinner
May 1, 1986·The Journal of Clinical Investigation·D D HoM S Hirsch
Feb 1, 1989·The Journal of Clinical Endocrinology and Metabolism·T S CroxsonB Zumoff
Mar 1, 1989·Human Pathology·M E De Paepe, M Waxman
Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·M R BlackmanS M Harman
Sep 24, 1987·The New England Journal of Medicine·N Sonino
Mar 1, 1988·The American Journal of Medicine·A S DobsB F Polk
Jun 1, 1988·Histopathology·C Rogers, E C Klatt
Feb 1, 1987·Endocrine Reviews·A D MooradianS G Korenman
Jun 1, 1987·Urology·A B ChabonH Grabstald
Mar 1, 1985·The Journal of Clinical Endocrinology and Metabolism·P D WoolfM Kelly
Jul 1, 1973·Journal of Steroid Biochemistry·S O'ConnorB Hudson
Oct 1, 1970·Steroids·S FuruyamaC A Nugent
Feb 4, 1993·The New England Journal of Medicine·G PantaleoA S Fauci

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Citations

Aug 26, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Shalender BhasinJames T Dalton
Jan 26, 2011·JAAPA : Official Journal of the American Academy of Physician Assistants·Bettie CoplanJames Roch
Jul 22, 2009·Journal of Strength and Conditioning Research·Jay R HoffmanAlan D Rogol
Aug 30, 2014·Endocrinology and Metabolism Clinics of North America·Vincenzo Rochira, Giovanni Guaraldi
Nov 4, 2004·Chemico-biological Interactions·Patricia E GaneyRobert A Roth
Dec 27, 2005·American Journal of Human Biology : the Official Journal of the Human Biology Council·P B GrayH H Vorster
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·B Salehian, K Kejriwal

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