PMID: 3747510Jul 1, 1986Paper

Testicular responsiveness to human chorionic gonadotrophin during transient hypogonadotrophic hypogonadism induced by androgenic/anabolic steroids in power athletes

Journal of Steroid Biochemistry
H MartikainenR Vihko

Abstract

Serum concentrations of testosterone, 17-hydroxyprogesterone, estradiol and several other unconjugated and sulphated steroids were analyzed before and after a single dose of hCG in 6 power athletes, who had used high doses of testosterone and anabolic steroids for 3 months. The study was carried out 3 weeks after cessation of drug use, but the study subjects were still characterized by hypogonadotrophic hypogonadism. The mean concentrations of serum LH and FSH were 2.6 +/- 0.3 and 1.1 +/- 0.03 mIU/ml (mean +/- SEM), respectively, and the concentrations of several precursors and metabolites of testosterone were lower than those before drug use. In contrast, circulating concentrations of steroid sulphates were not decreased, with the exception of dehydroepiandrosterone sulphate. After hCG injection serum testosterone and 5 alpha-dihydrotestosterone concentrations increased significantly, whereas no increases in estradiol and 17-hydroxyprogesterone concentrations were observed. These results demonstrate that during transient hypogonadotrophism in adult men, the testicular responsiveness to a single injection of hCG is similar to that in prepubertal boys without any sign of steroidogenic lesion at the 17,20-desmolase step. Therefor...Continue Reading

References

Jul 1, 1979·The Journal of Clinical Endocrinology and Metabolism·A G SmalsP W Kloppenborg
Jul 1, 1977·The Journal of Clinical Endocrinology and Metabolism·G L HammondR Vihko
Mar 1, 1980·The Journal of Clinical Investigation·S B CigorragaM L Dufau
Dec 1, 1981·International Journal of Andrology·H MartikainenR Vihko
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·V ToscanoB Boscherini
Nov 1, 1980·The Journal of Clinical Endocrinology and Metabolism·A G SmalsP W Kloppenborg

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Citations

Mar 21, 2012·Endocrine·Luigi Di LuigiAndrea Lenzi
Jun 1, 1991·British Journal of Sports Medicine·A T KicmanD A Cowan
Jul 21, 2006·Asian Journal of Andrology·Saied Karbalay-DoustHossien Mirkhani
May 16, 2009·Expert Opinion on Drug Metabolism & Toxicology·Jenny J SchulzeLena Ekström
May 1, 1995·The Journal of Urology·P J TurekL I Lipshultz
Mar 1, 1989·The Physician and Sportsmedicine·K E Friedl, C E Yesalis
Mar 20, 2014·Journal of Pharmacy Practice·Eric J IpPaul J Perry
May 1, 1993·The American Journal of Sports Medicine·H A Haupt
Jul 1, 1987·The American Journal of Sports Medicine·M AlènR Vihko
Jul 1, 1990·The American Journal of Sports Medicine·J P Jarow, L I Lipshultz
Jul 14, 2004·Sports Medicine·Fred Hartgens, Harm Kuipers
Feb 26, 2016·Orphanet Journal of Rare Diseases·Kinga Viktória KőhalmiHenriette Farkas
Nov 10, 2001·The Journal of Clinical Endocrinology and Metabolism·S BasariaA S Dobs
Apr 1, 1992·The Annals of Pharmacotherapy·D A Smith, P J Perry
Jul 22, 2009·Journal of Strength and Conditioning Research·Jay R HoffmanAlan D Rogol
Apr 23, 2021·Andrologia·José de Oliveira Vilar NetoElizabeth De Francesco Daher

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