Testicular sperm is superior to ejaculated sperm for ICSI in cryptozoospermia: An update systematic review and meta-analysis

Scientific Reports
Y-N KangChien-Chih Wu

Abstract

Intracytoplasmic sperm injection (ICSI) is well established and provides patients with severely impaired sperm quality with an opportunity to father a child. However, previous studies do not clearly indicate whether male with cryptozoospermia should use testicular sperm or ejaculated sperm for ICSI. The newest systematic review of this topic also gave a controversial conclusion that was based on incorrect pooling result. Moreover, two clinical studies published after the systematic review. In the present update systematic review and meta-analysis, a comprehensive citation search for relevant studies was performed using the Cochrane library databases, Embase, Ovid MEDLINE, PubMed, ScienceDirect, Scopus, and Web of Science up to September 2017. The search returned 313 records, in which six studies were included in quantitative synthesis. These studies involved 578 male infertility patients who had undergone 761 ICSI cycles. The risk ratios favour fresh testicular sperm for good quality embryo rate (1.17, 95% CI 1.05-1.30, P = 0.005), implantation rate (95% CI 1.02-2.26, P = 0.04), and pregnancy rate (RR = 1.74, 95% CI 1.20-2.52, P = 0.004). In conclusion, the existing evidence suggests that testicular sperm is better than ejacula...Continue Reading

References

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Citations

Oct 11, 2019·Archives of Gynecology and Obstetrics·Nathallie Louise Sandi-MonroyFriedrich Gagsteiger
Dec 12, 2019·F1000Research·Sandro C Esteves, Matheus Roque
Jul 9, 2021·Fertility and Sterility·Lauren M Kendall RauchfussChandra C Shenoy

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Methods Mentioned

BETA
sperm collection

Software Mentioned

Emtree
RevMan
Ovid
Comprehensive Meta - Analysis

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