Testicular teratocarcinogenesis in mice--a review

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Angabin MatinJ H Nadeau

Abstract

Spontaneous testicular germ cell tumours in humans and mice are remarkable for their diverse composition. These tumours are usually composed of an extraordinary variety of cell and tissue types including muscle, skin, bone, cartilage, and neuroepithelia. Their diverse composition reflects their origin from totipotent primordial germ cells at about Day 12 of fetal development. Although much is known about the development of these tumours, remarkably little is known about the genetics of the mammalian primordial germ cell lineage or about the genes that control susceptibility to spontaneous testicular germ cell tumours in humans or mice. Conventional genetic analysis of susceptible 129/Sv mice is difficult because of the large number of susceptibility genes and their low penetrance. We are taking advantage of the Ter mutation to simplify the genetic analysis. Various evidence suggests that Ter is neither necessary nor sufficient for tumourigenesis. Instead, Ter acts as a modifier, dramatically increasing tumour incidence from approximately 1% in +/+ males, to approximately 17% in Ter/+ males and approximately 94% in Ter/Ter males. Segregation analysis suggests that Ter increases tumour incidence by requiring some, but perhaps not...Continue Reading

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Citations

Aug 12, 2005·Cell and Tissue Research·Catherine M BrowneKate L Loveland
Oct 11, 2003·Current Opinion in Genetics & Development·Peter J Donovan, Maria P de Miguel
Mar 24, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Yun-Fai Chris LauTatsuo Kido
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Jul 2, 1999·British Journal of Cancer·J SundströmP Pöllänen
Feb 10, 2006·International Journal of Andrology·Kristian AlmstrupEwa Rajpert-De Meyts

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