PMID: 9441133Jun 1, 1997Paper

Testing airway responsiveness using inhaled methacholine or histamine

Respirology : Official Journal of the Asian Pacific Society of Respirology
A James, G Ryan

Abstract

Airway responsiveness assessed using histamine and methacholine is safe, reproducible and relatively easily undertaken in adults and children. Results are similar for methacholine and histamine although methacholine is better tolerated. Responsiveness is increased in children and the elderly, and in women compared to men, possibly due to body size effects. Baseline lung function confounds the interpretation of airway responsiveness and may explain the effect of smoking in most studies. Results are most usefully expressed as the provocative dose producing a 20% fall in FEV1 (PD20FEV1) or the dose-response slope (DRS). When technical factors are controlled the reproducibility of the test is from one to two doubling doses. Measurements of airway responsiveness have been widely used in clinical and research practice. However, assessing their value in diagnosing asthma is limited by the lack of a gold standard for the definition of asthma. Using a cut-off value of 8 mg/mL or 8 mumol for PD20, the tests will discriminate asthmatic from non-asthmatic subjects (based on questionnaire definitions of asthma) with a sensitivity of around 60% and a specificity of around 90%. These properties of the test result in positive and negative pred...Continue Reading

References

Dec 1, 1979·The Journal of Allergy and Clinical Immunology·R G TownleyK M Burke
Feb 1, 1978·The Journal of Allergy and Clinical Immunology·R K BushC E Reed
May 1, 1977·Clinical Allergy·D W CockcroftF E Hargreave
Jan 1, 1976·Clinical Notes on Respiratory Diseases·B BurrowsR A Barbee
Oct 1, 1975·The Journal of Allergy and Clinical Immunology·H ChaiR G Townley
Feb 1, 1976·Annals of Internal Medicine·B BurrowsR A Barbee
Oct 1, 1992·The American Review of Respiratory Disease·A JamesB Musk
Nov 28, 1992·BMJ : British Medical Journal·J K PeatA J Woolcock
Sep 1, 1992·The American Review of Respiratory Disease·B G ToelleA J Woolcock
Jan 1, 1992·The Journal of Allergy and Clinical Immunology·D W CockcroftB P Gore
Mar 1, 1990·The Journal of Allergy and Clinical Immunology·J CôtéM Chan-Yeung
Sep 1, 1990·The American Review of Respiratory Disease·D W Cockcroft, F E Hargreave
Sep 1, 1990·The American Review of Respiratory Disease·P K PattemoreA W Stewart
Dec 1, 1990·The American Review of Respiratory Disease·S M KennedyM Chan-Yeung
Dec 1, 1990·Thorax·M J AbramsonM J Hensley
Jan 1, 1989·The Journal of Clinical Investigation·R F LemanskeW W Busse
Aug 1, 1989·The American Review of Respiratory Disease·L K JosephsS T Holgate
Dec 1, 1989·The American Review of Respiratory Disease·G T O'ConnorS T Weiss
Jan 1, 1989·The American Review of Respiratory Disease·P N LesouëfL I Landau
Jun 1, 1988·The American Review of Respiratory Disease·W S BeckettN D Wong
Mar 1, 1988·Age and Ageing·M J ConnollyD J Hendrick
Dec 1, 1987·The American Review of Respiratory Disease·G O'ConnorS Weiss
Jul 1, 1987·The American Review of Respiratory Disease·B RijckenR van der Lende
Oct 1, 1987·Journal of Applied Physiology·P J ManningP M O'Byrne
May 1, 1986·The Journal of Allergy and Clinical Immunology·C WittR L Dawkins

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Citations

Oct 25, 2002·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·S D AndersonH-K Chan
Feb 5, 2005·Respirology : Official Journal of the Asian Pacific Society of Respirology·Alan L JamesJohn G Elliot
Aug 21, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Norbert BerendGreg G King
Jun 3, 1999·American Journal of Respiratory and Critical Care Medicine·J M ChatkinK R Chapman
Dec 3, 2003·American Journal of Respiratory and Critical Care Medicine·Andrew D SmithD Robin Taylor
Jul 14, 2009·BMC Pulmonary Medicine·Antonius SchneiderJoachim Szecsenyi
Jan 27, 2004·American Journal of Respiratory and Critical Care Medicine·Jacqui Joseph-BowenPeter D Sly
Oct 12, 2010·The Journal of Allergy and Clinical Immunology·Asger SverrildVibeke Backer
Jun 29, 2004·Pulmonary Pharmacology & Therapeutics·K Racké, S Matthiesen
Aug 13, 2015·Occupational and Environmental Medicine·Anneli C S BolundVivi Schlünssen
Jul 6, 2011·Respiratory Medicine·Madison T YurachDonald W Cockcroft
Oct 31, 2012·Respiratory Medicine·Antonius SchneiderRudolf A Jörres
Dec 13, 2002·Respiratory Medicine·B G ToelleS G Devadason
Nov 11, 2017·Applied Psychophysiology and Biofeedback·Paul M LehrerFrederick S Wamboldt
Jun 22, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H VallyN L A Misso
May 15, 2007·Journal of Applied Physiology·Elizabeth M BozanichPeter D Sly

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