Testing alternative regression models to predict utilities: mapping the QLQ-C30 onto the EQ-5D-5L and the SF-6D

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
Admassu N Lamu, Jan Abel Olsen

Abstract

The purpose of the study was to compare alternative statistical techniques to find the best approach for converting QLQ-C30 scores onto EQ-5D-5L and SF-6D utilities, and to estimate the mapping algorithms that best predict these health state utilities. 772 cancer patients described their health along the cancer-specific instrument (QLQ-C30) and two generic preference-based instruments (EQ-5D-5L and SF-6D). Seven alternative regression models were applied: ordinary least squares, generalized linear model, extended estimating equations (EEE), fractional regression model, beta binomial (BB) regression, logistic quantile regression and censored least absolute deviation. Normalized mean absolute error (NMAE), normalized root mean square error (NRMSE), r-squared (r2) and concordance correlation coefficient (CCC) were used as model performance criteria. Cross-validation was conducted by randomly splitting internal dataset into two equally sized groups to test the generalizability of each model. In predicting EQ-5D-5L utilities, the BB regression performed best. It gave better predictive accuracy in terms of all criteria in the full sample, as well as in the validation sample. In predicting SF-6D, the EEE performed best. It outperforme...Continue Reading

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Citations

Jun 4, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Rajan SharmaBonny Parkinson
May 28, 2019·Journal of Medical Economics·Ariane K KawataHuamao M Lin
Apr 18, 2020·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Admassu N Lamu
May 1, 2020·Health and Quality of Life Outcomes·Sanjeewa KularatnaWilliam Parsonage
Dec 19, 2020·Health and Quality of Life Outcomes·Christoph Paul KlapprothF Fischer
Nov 5, 2020·Health and Quality of Life Outcomes·Yasuhiro HagiwaraKojiro Shimozuma
Jun 3, 2021·Scientific Reports·Yanling ZhengJing Wang
Sep 24, 2021·Applied Health Economics and Health Policy·Aurelie MeunierLouise Longworth
Dec 1, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Richard Huan XuShuyang Zhang

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