Testing and analytical procedures for laboratory studies involving nonresponders during a limited observation period: an illustration using male sexual behavior in rats

Pharmacology, Biochemistry, and Behavior
D L Rowland, J A Thornton

Abstract

In many laboratory studies, a subpopulation of subjects fails to exhibit the response under investigation during the period of observation. For example, within any population of male rats, there is significant variation in the expression of sexual behavior in the presence of a receptive female. Some males may never display the full sequence of behaviors leading to ejaculation within the typical time frame of the testing session, with the resulting lack of behavioral response presenting problems in the analysis of the data. Conventional strategies range from screening such males from the study or dropping them from the analysis to constructing new variables based on estimates from existing parameters or increasing the length of the test session to capture sexual responses in a greater portion of males. Herein, we present an alternative strategy for analyzing data where outcomes are absent due to the limited observation period. Survival regression analysis enables inclusion of all subjects in the analysis whether or not they have shown the behavior of interest. Use of such a strategy not only has potential to reveal new results but also guards against bias from excluding nonresponders from the study or dropping more males from on...Continue Reading

References

Jan 1, 1978·Archives of Sexual Behavior·L Wolfe
Jan 14, 1992·European Journal of Pharmacology·A Fernández-GuastiK Larsson
Aug 6, 1991·European Journal of Pharmacology·S AhleniusA Wijkström
Oct 1, 1991·Pharmacology, Biochemistry, and Behavior·S M HaenselA K Slob
Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·E R SmithJ M Davidson
Dec 1, 1989·Brain Research Bulletin·F H De JongeN E van de Poll
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·D Bitran, E M Hull
Jan 1, 1986·Physiology & Behavior·S D Mendelson, B B Gorzalka
Jun 30, 1994·Behavioural Brain Research·E J HoutsmullerD L Rowland
Jun 4, 1998·Pharmacology, Biochemistry, and Behavior·D L Rowland, E J Houtsmuller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Applied Nursing Research : ANR
Susan K DeCraneJacqueline M Leung
Proceedings of the Royal Society of Medicine
L S PENROSE
AIDS Education and Prevention : Official Publication of the International Society for AIDS Education
Ronald G ThompsonDana Alonzo
© 2021 Meta ULC. All rights reserved